RESUMO
The impossibility to identify cancer in the final surgical specimen has been reported in some patients with prostate cancer undergoing radical prostatectomy. This has been attributed to either a wrong diagnosis or pathological technique, or to spontaneous or biopsy-induced cure of the tumor. This study assessed the incidence of vanishing prostate cancer in our department for 12 years, the clinical characteristics of patients, and their follow-up. The initial puncture biopsies were also re-evaluated using inmunohistochemical stains. Prostate cancer could not be confirmed in the surgical specimen in six out of 346 operated patients (1.73%) receiving no neoadjuvant therapy. When the initial biopsies were reviewed, cancer was only confirmed in three patients. Incidence of vanishing cancer at our department in the 12-year period considered was 0.86% (3/346). No tumor relapse occurred during 4.5 years of follow-up.
Assuntos
Neoplasias da Próstata/patologia , Biópsia por Agulha , Humanos , Masculino , Neoplasias da Próstata/epidemiologiaRESUMO
Eosinophilic cystitis is a low frequency disease, with less than 200 reported cases in the world. It is characterized by a bladder wall inflammation, mainly by eosinophils, with fibrosis and muscle necrosis areas. Its origin seems to be immunological, although the triggers are not well known. Several predispose factor have been described such as allergic diseases, bladder injuries, drugs, infections, etc. It affects patient of all ages, mainly adults. It presents with frecuency, haematuria and suprapubic pain. Other less frequent symptoms are disuria, urinary retention, nicturia, and enuresis. The laboratory study (urinalysis, urinalysis and haemogram) and radiology (ultrasound, intravenous pyelography, computed tomography and nuclear magnetic resonance) are non specific. The lesions observed in the cystoscopy could emulate other diseases, that why the proper diagnostic is the histological analysis. The management could be observation o antihistaminic, anti-inflammatory and corticoid treatment. In refractory cases, surgery is an alternative. In this work, two male adult cases are reported with their symptoms, studies and management.
Assuntos
Cistite , Eosinofilia , Adulto , Cistite/diagnóstico , Cistite/terapia , Eosinofilia/diagnóstico , Eosinofilia/terapia , Humanos , MasculinoRESUMO
La cistitis eosinofílica es una enfermedad de baja frecuencia, con menos de 200 casos reportados en el mundo. Se caracteriza por la inflamación de toda la pared vesical, predominantemente por eosinófilos, con fibrosis y áreas de necrosis muscular. Su origen parece ser inmunológico aunque los desencadenantes no se conocen bien. Se han descrito varios factores predisponentes como enfermedades alérgicas, trauma vesical, fármacos, infecciones, etc. Afecta a pacientes de todas las edades, preferentemente adultos. Se presenta con polaquiuria, hematuria y dolor suprapúbico. Otros de menor frecuencia son disuria, retención urinaria, nicturia y enuresis. El estudio de laboratorio (sedimento de orina, urocultivo, hemograma)y radiológico (ecotomografía, pielografía de eliminación, tomografía computada y resonancia nuclear magnética) son inespecíficos. En la cistoscopía se observan lesiones que pueden simular otras enfermedades, por lo que el diagnóstico definitivo es histológico. El manejo puede ser expectante o con antihistamínicos, antiinflamatorios y corticoides. En los casos refractarios al tratamiento médico la cirugía puede ser una alternativa. Reportamos dos casos de pacientes hombres, adultos, con su cuadro de presentación, estudio y manejo (AU)
Eosinophilic cystitis is a low frequency disease, with less than 200 reported cases in the world. It is characterized by a bladder wall inflammation, mainly by eosinophils, with fibrosis and muscle necrosis areas. Its origin seems to be immunological, although the triggers are not well known. Several predispose factor have been described such as allergic diseases, bladder injuries, drugs, infections, etc. It affects patient of all ages, mainly adults. It presents with frecuency, haematuria and suprapubic pain. Other less frequent symptoms are disuria, urinary retention, nicturia, and enuresis. The laboratory study(urinalysis, urinalysis and haemogram) and radiology (ultrasound, intravenous pyelography, computed tomography and nuclear magnetic resonance) are non specific. The lesions observed in the cystoscopy could emulate other diseases, that why the proper diagnostic is the histological analysis. The management could be observation o antihistaminic, anti-inflammatory and corticoid treatment. In refractory cases, surgery is an alternative. In this work, two male adult cases are reported with their symptoms, studies and management (AU)