Detalhe da pesquisa
1.
IP-LC-MSMS Enables Identification of Three Tau O-GlcNAcylation Sites as O-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau.
J Proteome Res
; 22(4): 1309-1321, 2023 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36888912
2.
SliceMap: an algorithm for automated brain region annotation.
Bioinformatics
; 34(4): 718-720, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29048461
3.
Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-ß burden in several amyloid transgenic mouse models.
Glia
; 66(3): 492-504, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29134678
4.
Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.
Alzheimers Dement
; 14(10): 1261-1280, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30036493
5.
Generation of three isogenic, gene-edited iPSC lines carrying the APOE-Christchurch mutation into the three common APOE variants: APOE2Ch, APOE3Ch and APOE4Ch.
Stem Cell Res
; 77: 103414, 2024 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38703665
6.
Scalable expansion of iPSC and their derivatives across multiple lineages.
Reprod Toxicol
; 112: 23-35, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35595152
7.
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.
J Biol Chem
; 285(17): 12873-81, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20106978
8.
Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies.
Stem Cell Res
; 54: 102386, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34229210
9.
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Æ2/Æ3/Æ4) and knock-out for the study of APOE biology in health and disease.
Stem Cell Res
; 52: 102180, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33556820
10.
SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System.
Stem Cell Rev Rep
; 17(5): 1855-1873, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33982246
11.
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates.
Sci Rep
; 11(1): 17977, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34504195
12.
The EBiSC iPSC bank for disease studies.
Stem Cell Res
; 49: 102034, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33099110
13.
Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders.
J Med Chem
; 63(22): 14017-14044, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33197187
14.
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.
J Med Chem
; 63(15): 8608-8633, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32662649
15.
Fragment-based discovery of BACE1 inhibitors using functional assays.
Biochemistry
; 48(45): 10743-51, 2009 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19799414
16.
Morpholine containing CB2 selective agonists.
Bioorg Med Chem Lett
; 19(6): 1604-9, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19243942
17.
Deploying human pluripotent stem cells to treat central nervous system disorders: facts, challenges and realising the potential.
Stem Cell Res
; 41: 101581, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31812872
18.
Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aß Phagocytosis.
iScience
; 19: 110-118, 2019 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31369984
19.
Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line.
Stem Cell Res
; 34: 101349, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30660866
20.
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
Bioorg Med Chem Lett
; 18(5): 1725-9, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18255291