Detalhe da pesquisa
1.
A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system.
Nucleic Acids Res
; 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38726879
2.
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.
Nucleic Acids Res
; 2024 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38613388
3.
A combinatorial approach for achieving CNS-selective RNAi.
Nucleic Acids Res
; 2024 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38348876
4.
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.
Nucleic Acids Res
; 52(2): 977-997, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38033325
5.
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Proc Natl Acad Sci U S A
; 120(11): e2219523120, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893269
6.
Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.
Nucleic Acids Res
; 50(15): 8418-8430, 2022 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35920332
7.
Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease.
Alzheimers Dement
; 20(4): 2632-2652, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38375983
8.
RNAi-based modulation of IFN-γ signaling in skin.
Mol Ther
; 30(8): 2709-2721, 2022 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35477658
9.
An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis.
Mol Ther
; 30(3): 1329-1342, 2022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34774753
10.
Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.
Nucleic Acids Res
; 49(21): 12069-12088, 2021 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34850120
11.
Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.
Nucleic Acids Res
; 47(3): 1082-1096, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30544191
12.
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Nucleic Acids Res
; 47(3): 1070-1081, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30535404
13.
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Nucleic Acids Res
; 46(5): 2185-2196, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432571
14.
Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles.
Mol Ther
; 26(6): 1520-1528, 2018 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29699940
15.
Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.
Mol Ther
; 26(8): 1973-1982, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29937418
16.
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
Mol Ther
; 26(11): 2580-2591, 2018 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30143435
17.
5Î-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
Nucleic Acids Res
; 45(13): 7581-7592, 2017 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28591791
18.
Visualization of self-delivering hydrophobically modified siRNA cellular internalization.
Nucleic Acids Res
; 45(1): 15-25, 2017 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27899655
19.
Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo.
Bioconjug Chem
; 29(7): 2478-2488, 2018 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29898368
20.
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.
Bioconjug Chem
; 28(6): 1758-1766, 2017 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28462988