Detalhe da pesquisa
1.
Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species.
Bioorg Med Chem Lett
; 28(6): 1122-1126, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534798
2.
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
J Med Chem
; 66(2): 1157-1171, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36624931
3.
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
ACS Med Chem Lett
; 14(8): 1088-1094, 2023 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37583812
4.
Impact of acute nicotine exposure on monoaminergic systems in adolescent and adult male and female rats.
Neurotoxicol Teratol
; 93: 107122, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36116700
5.
Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment.
Nat Aging
; 2(10): 923-940, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36636325
6.
Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.
Clin Transl Sci
; 14(4): 1490-1504, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33742760
7.
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition.
Neurotoxicology
; 29(3): 489-503, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18313142
8.
Mercury-induced cognitive impairment in metallothionein-1/2 null mice.
Neurotoxicol Teratol
; 30(2): 88-95, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18226494
9.
Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion.
Nat Med
; 23(1): 39-48, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27892953
10.
Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion, and altered sensory function in mice.
Sci Rep
; 6: 30757, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476972
11.
Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models.
Science
; 344(6188): 1178-82, 2014 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24904170
12.
The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey.
Psychopharmacology (Berl)
; 231(3): 511-9, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24051602
13.
The nicotinic α7 receptor agonist GTS-21 improves cognitive performance in ketamine impaired rhesus monkeys.
Neuropharmacology
; 64: 191-6, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22659472
14.
The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque.
Psychopharmacology (Berl)
; 225(1): 21-30, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22825578
15.
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.
Neuropharmacology
; 64: 215-23, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22750078
16.
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition.
Sci Transl Med
; 5(179): 179ra44, 2013 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23552372
17.
Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits.
Neurotoxicol Teratol
; 32(1): 99-108, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-19268529
18.
Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze.
Brain Res
; 1308: 147-52, 2010 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854162
19.
Nicotine effects on learning in zebrafish: the role of dopaminergic systems.
Psychopharmacology (Berl)
; 202(1-3): 103-9, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18716760
20.
Hippocampal infusions of apolipoprotein E peptides induce long-lasting cognitive impairment.
Brain Res Bull
; 79(2): 111-5, 2009 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19185602