Detalhe da pesquisa
1.
Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages.
RNA
; 22(3): 350-9, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26742993
2.
The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes.
J Biol Chem
; 290(46): 27524-31, 2015 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26408199
3.
Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene.
Org Biomol Chem
; 14(23): 5263-71, 2016 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27188838
4.
Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.
J Biol Chem
; 289(4): 1938-47, 2014 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24302718
5.
Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives.
J Org Chem
; 79(12): 5697-709, 2014 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24873648
6.
A deep learning approach to identify gene targets of a therapeutic for human splicing disorders.
Nat Commun
; 12(1): 3332, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34099697
7.
Small molecule splicing modifiers with systemic HTT-lowering activity.
Nat Commun
; 12(1): 7299, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34911927
8.
Modulating splicing with small molecular inhibitors of the spliceosome.
Wiley Interdiscip Rev RNA
; 8(2)2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27440103
9.
Total synthesis of GEX1Q1, assignment of C-5 stereoconfiguration and evaluation of spliceosome inhibitory activity.
Org Lett
; 16(11): 3154-7, 2014 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24869489
10.
Enantioselective synthesis of spliceostatin E and evaluation of biological activity.
Org Lett
; 16(23): 6200-3, 2014 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25423085
11.
A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes.
J Biomol Screen
; 18(9): 1110-20, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23771823