Detalhe da pesquisa
1.
Evolution of Biocatalysis at Novartis over the last 40 Years.
Chimia (Aarau)
; 77(6): 376-383, 2023 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38047776
2.
Disposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects.
Xenobiotica
; 50(2): 150-169, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31006307
3.
A novel cytochrome P450 mono-oxygenase from Streptomyces platensis resembles activities of human drug metabolizing P450s.
Biotechnol Bioeng
; 115(9): 2156-2166, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29943426
4.
Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro.
Drug Metab Dispos
; 45(7): 817-825, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28442499
5.
Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.
Drug Metab Dispos
; 44(5): 653-64, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26921386
6.
Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis.
Microb Cell Fact
; 14: 82, 2015 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26062974
7.
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.
Cell Chem Biol
; 28(10): 1407-1419.e6, 2021 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33794192
8.
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
J Med Chem
; 63(19): 10773-10781, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667203
9.
Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes.
Genome Announc
; 5(28)2017 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28705965
10.
Human xanthine oxidase recombinant in E. coli: A whole cell catalyst for preparative drug metabolite synthesis.
J Biotechnol
; 235: 3-10, 2016 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27021957