Detalhe da pesquisa
1.
In situ evaluation of the impact of metformin or verapamil coadministration with vildagliptin on its regional absorption from the rabbit's intestine.
Biopharm Drug Dispos
; 45(2): 71-82, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38400763
2.
Delineating the role of cooperativity in the design of potent PROTACs for BTK.
Proc Natl Acad Sci U S A
; 115(31): E7285-E7292, 2018 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012605
3.
Navigating Transporter Sciences in Pharmacokinetics Characterization Using the Extended Clearance Classification System.
Drug Metab Dispos
; 46(5): 729-739, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29496721
4.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 346-356, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330218
5.
Involvement of Drug Transporters in Organ Toxicity: The Fundamental Basis of Drug Discovery and Development.
Chem Res Toxicol
; 29(4): 545-63, 2016 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26889774
6.
Projecting ADME Behavior and Drug-Drug Interactions in Early Discovery and Development: Application of the Extended Clearance Classification System.
Pharm Res
; 33(12): 3021-3030, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27620173
7.
Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).
Pharm Res
; 32(12): 3785-802, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26155985
8.
Development and validation of an UPLC-MS/MS assay for quantitative analysis of the ghrelin receptor inverse agonist PF-5190457 in human or rat plasma and rat brain.
Anal Bioanal Chem
; 407(19): 5603-13, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25943263
9.
Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin.
Drug Metab Dispos
; 41(5): 966-74, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23393219
10.
Quantitative prediction of renal transporter-mediated clinical drug-drug interactions.
Mol Pharm
; 10(11): 4207-15, 2013 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24066726
11.
Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide.
Pharm Res
; 30(4): 1188-99, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23307347
12.
Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion.
Drug Metab Dispos
; 40(8): 1527-37, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22580868
13.
In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.
Drug Metab Dispos
; 40(6): 1085-92, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22381335
14.
Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.
Drug Metab Dispos
; 40(5): 1007-17, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22344703
15.
Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes.
Drug Metab Dispos
; 40(2): 407-11, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22031626
16.
Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes.
Mol Pharm
; 9(12): 3535-42, 2012 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23082789
17.
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.
Mol Pharm
; 9(5): 1199-212, 2012 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22489626
18.
Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration.
Xenobiotica
; 42(1): 11-27, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21970687
19.
Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants.
J Pharmacol Exp Ther
; 338(2): 615-21, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21558437
20.
pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.
Mol Pharm
; 8(4): 1303-13, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21710988