Detalhe da pesquisa
1.
Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kß kinases.
J Enzyme Inhib Med Chem
; 39(1): 2311157, 2024 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38348846
2.
Synthesis of 3-Aminoquinazolinones via a SnCl2-Mediated ANRORC-like Reductive Rearrangement of 1,3,4-Oxadiazoles.
J Org Chem
; 88(24): 17062-17068, 2023 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38016045
3.
Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs.
Bioorg Chem
; 135: 106502, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37030108
4.
A New Avenue for Enhanced Treatment of Hyperuricemia and Oxidative Stress: Design, Synthesis and Biological Evaluation of Some Novel Mutual Prodrugs Involving Febuxostat Conjugated with Different Antioxidants.
Bioorg Chem
; 140: 106818, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37688830
5.
Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies.
J Enzyme Inhib Med Chem
; 38(1): 2202357, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37092260
6.
Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.
J Enzyme Inhib Med Chem
; 38(1): 2201407, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37078173
7.
Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity.
Bioorg Chem
; 119: 105554, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34923243
8.
Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease.
J Enzyme Inhib Med Chem
; 37(1): 2112-2132, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35912578
9.
Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRß/γ selective agonist to ERRα/ß/γ pan agonists.
Bioorg Chem
; 102: 104079, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32683181
10.
Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy.
Bioorg Chem
; 105: 104352, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33080494
11.
Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors.
Bioorg Chem
; 99: 103782, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32229348
12.
An Efficient Greener Approach for N-Acylation of Amines in Water Using Benzotriazole Chemistry.
Molecules
; 25(11)2020 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32481504
13.
Development of novel liverâ¯Xâ¯receptor modulators based on a 1,2,4-triazole scaffold.
Bioorg Med Chem Lett
; 29(3): 449-453, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30587446
14.
Baclofen impurities: Facile synthesis and novel environmentally benign chromatographic method for their simultaneous determination in baclofen.
Biomed Chromatogr
; 33(9): e4579, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31077429
15.
Efficient UPLC and CE methods for the simultaneous determination of azelastine hydrochloride and its genotoxic impurity.
Biomed Chromatogr
; 32(11): e4346, 2018 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30045415
16.
Macrocyclic peptidomimetics with antimicrobial activity: synthesis, bioassay, and molecular modeling studies.
Org Biomol Chem
; 13(36): 9492-503, 2015 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26256838
17.
Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors.
Bioorg Med Chem Lett
; 23(7): 2007-13, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23453843
18.
4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments.
Eur J Med Chem
; 250: 115180, 2023 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36796297
19.
Traceless chemical ligations from O-acyl serine sites.
Org Biomol Chem
; 10(25): 4836-8, 2012 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22635203
20.
Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines.
Curr Pharm Des
; 28(3): 198-207, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34176458