Detalhe da pesquisa
1.
Characterization of the Major Purine and Pyrimidine Adducts Formed after Incubations of 1-Chloro-3-buten-2-one with Single-/Double-Stranded DNA and Human Cells.
Chem Res Toxicol
; 30(2): 552-563, 2017 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27977153
2.
Identification of a Fused-Ring 2'-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1-Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene.
Chem Res Toxicol
; 29(6): 1041-50, 2016 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27161607
3.
Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene.
Toxicol Appl Pharmacol
; 267(1): 1-10, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23253325
4.
Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene.
Toxicol Appl Pharmacol
; 271(1): 13-9, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23643860
5.
Formation of fused-ring 2'-deoxycytidine adducts from 1-chloro-3-buten-2-one, an in vitro 1,3-butadiene metabolite, under in vitro physiological conditions.
Chem Res Toxicol
; 26(10): 1545-53, 2013 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24020501
6.
Alcohol dehydrogenase- and rat liver cytosol-dependent bioactivation of 1-chloro-2-hydroxy-3-butene to 1-chloro-3-buten-2-one, a bifunctional alkylating agent.
Chem Res Toxicol
; 25(11): 2600-7, 2012 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23110628
7.
N-biotinyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide as a potential model for S-(1,2-dichlorovinyl)-L-cysteine sulfoxide: characterization of stability and reactivity with glutathione and kidney proteins in vitro.
Chem Res Toxicol
; 24(11): 1915-23, 2011 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21988407
8.
Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
J Pharmacol Exp Ther
; 329(3): 1148-55, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19307449
9.
Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: potential roles in toxicity.
Toxicol Appl Pharmacol
; 236(3): 358-65, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19236888
10.
Formation of mono- and bis-Michael adducts by the reaction of nucleophilic amino acids with hydroxymethylvinyl ketone, a reactive metabolite of 1,3-butadiene.
Chem Res Toxicol
; 22(5): 918-25, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19317513
11.
Mass spectral analyses of hydroxymethylvinyl ketone-hemoglobin adducts formed after in vivo exposure of Sprague-Dawley rats to 3-butene-1,2-diol.
Chem Res Toxicol
; 22(6): 1163-71, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19419228
12.
Globin monoadducts and cross-links provide evidence for the presence of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, chlorothioketene, and 2-chlorothionoacetyl chloride in the circulation in rats administered S-(1,2-dichlorovinyl)-L-cysteine.
Chem Res Toxicol
; 22(9): 1629-38, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19694420
13.
Cysteine conjugate beta-lyase activity of rat erythrocytes and formation of beta-lyase-derived globin monoadducts and cross-links after in vitro exposure of erythrocytes to S-(1,2-dichlorovinyl)-L-cysteine.
Chem Res Toxicol
; 22(7): 1351-8, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19572755
14.
L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination.
J Pharmacol Exp Ther
; 326(3): 809-17, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18552130
15.
Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes.
Drug Metab Dispos
; 36(12): 2468-74, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18775983
16.
L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid.
Drug Metab Dispos
; 36(11): 2252-60, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18687801
17.
Detection of multiple globin monoadducts and cross-links after in vitro exposure of rat erythrocytes to S-(1,2-dichlorovinyl)-L-cysteine sulfoxide and after in vivo treatment of rats with S-(1,2-dichlorovinyl)-L-cysteine sulfoxide.
Chem Res Toxicol
; 21(9): 1716-25, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18681461
18.
Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design.
Expert Opin Drug Discov
; 13(9): 815-824, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30101640
19.
Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.
Biochem Pharmacol
; 73(11): 1829-41, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17433263
20.
Mass spectral analyses of hemoglobin adducts formed after in vitro exposure of erythrocytes to hydroxymethylvinyl ketone.
Chem Biol Interact
; 166(1-3): 176-81, 2007 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16735035