Detalhe da pesquisa
1.
Updated protein domain annotation of the PARP protein family sheds new light on biological function.
Nucleic Acids Res
; 51(15): 8217-8236, 2023 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37326024
2.
Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.
Bioorg Med Chem Lett
; 60: 128588, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35104640
3.
Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer.
Bioorg Med Chem Lett
; 30(8): 127040, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32085971
4.
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
Nature
; 508(7495): 222-7, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695225
5.
Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.
Biochem J
; 476(7): 1037-1051, 2019 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858169
6.
Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors.
J Org Chem
; 84(21): 14187-14201, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31460764
7.
Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).
Molecules
; 24(22)2019 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31698822
8.
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.
Nat Chem Biol
; 12(10): 876-84, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571479
9.
Correction: Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.
Org Biomol Chem
; 16(2): 336, 2018 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29256564
10.
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.
Bioorg Med Chem
; 26(11): 2965-2972, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29567296
11.
Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.
Org Biomol Chem
; 15(40): 8655-8660, 2017 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28984325
12.
Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles.
Angew Chem Int Ed Engl
; 56(22): 6264-6267, 2017 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28267269
13.
The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
Biochem J
; 464(2): 231-9, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25186459
14.
Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.
Eur J Med Chem
; 269: 116292, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38479168
15.
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.
J Med Chem
; 67(9): 7245-7259, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38635563
16.
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.
J Med Chem
; 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38780468
17.
Structural insights into the activation of MST3 by MO25.
Biochem Biophys Res Commun
; 431(3): 604-9, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23296203
18.
Recent advances in the structural biology of tyrosine kinases.
Curr Opin Struct Biol
; 82: 102665, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37562149
19.
Analysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria.
Protein Expr Purif
; 81(1): 136-143, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21985771
20.
Fragment screening of cyclin G-associated kinase by weak affinity chromatography.
Anal Bioanal Chem
; 404(8): 2417-25, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22918538