Detalhe da pesquisa
1.
The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.
Bioorg Med Chem
; 28(23): 115791, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33059303
2.
CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma.
J Chem Inf Model
; 56(6): 1063-77, 2016 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27149958
3.
2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity.
Bioorg Med Chem Lett
; 20(2): 673-8, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20006497
4.
Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.
J Med Chem
; 50(1): 2-5, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201404
5.
Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.
Structure
; 24(5): 774-781, 2016 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27066749
6.
Insights into catalysis by a knotted TrmD tRNA methyltransferase.
J Mol Biol
; 333(5): 931-49, 2003 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-14583191
7.
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.
J Med Chem
; 46(9): 1627-35, 2003 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12699381
8.
Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
ACS Med Chem Lett
; 1(1): 39-43, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900173
9.
Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.
J Med Chem
; 51(21): 6631-4, 2008 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842034
10.
Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase.
Acta Crystallogr D Biol Crystallogr
; 58(Pt 7): 1182-92, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12077439