Detalhe da pesquisa
1.
Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application.
Pharmacol Rev
; 64(3): 520-39, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22544865
2.
Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 3): 253-60, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22349227
3.
Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors.
Chemistry
; 17(23): 6369-81, 2011 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21538606
4.
Aromatic rings in chemical and biological recognition: energetics and structures.
Angew Chem Int Ed Engl
; 50(21): 4808-42, 2011 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21538733
5.
Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing.
ACS Med Chem Lett
; 10(11): 1537-1542, 2019 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749907
6.
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J Med Chem
; 61(6): 2533-2551, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29485874
7.
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
ACS Chem Biol
; 12(8): 1986-1992, 2017 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679043
8.
Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor.
Angew Chem Int Ed Engl
; 48(48): 9092-6, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19882607
9.
Entirely artificial signal transduction with adrenaline.
J Recept Signal Transduct Res
; 26(5-6): 473-85, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17118794