Detalhe da pesquisa
1.
The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects.
Drug Metab Dispos
; 51(5): 599-609, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36878717
2.
Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia.
J Pharmacokinet Pharmacodyn
; 50(5): 351-364, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37243877
3.
Population pharmacokinetics and exposure-response modeling and simulation for evolocumab in healthy volunteers and patients with hypercholesterolemia.
J Pharmacokinet Pharmacodyn
; 45(3): 505-522, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29736889
4.
Intestinal and hepatic first-pass extraction of the 11ß-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters.
Xenobiotica
; 44(3): 264-9, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23517558
5.
Activity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate.
Xenobiotica
; 43(7): 617-27, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23244593
6.
Phase 1, Single- and Multiple-Ascending-Dose, Food-Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase.
Clin Pharmacol Drug Dev
; 12(10): 1022-1035, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37477389
7.
Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation.
Pharmaceutics
; 15(5)2023 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37242718
8.
Regiospecific and stereospecific triangulation of the structures of metabolites formed by sequential metabolism at multiple prochiral centers.
Drug Metab Dispos
; 40(5): 928-42, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22328582
9.
Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors.
Drug Metab Dispos
; 40(12): 2239-49, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22930276
10.
Pharmacokinetics of bempedoic acid in patients with renal impairment.
Clin Transl Sci
; 15(3): 789-798, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34800002
11.
Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose-response model.
Eur Heart J Cardiovasc Pharmacother
; 8(6): 578-586, 2022 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34448822
12.
Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers.
Clin Transl Sci
; 14(6): 2487-2496, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34463032
13.
Influence of Renal Function on Evolocumab Exposure, Pharmacodynamics, and Safety.
Clin Pharmacol Drug Dev
; 8(3): 281-289, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30676701
14.
Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor.
Clin Pharmacokinet
; 57(7): 769-779, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29353350
15.
Comparison of LDL-C Reduction Using Different Evolocumab Doses and Intervals: Biological Insights and Treatment Implications.
J Cardiovasc Pharmacol Ther
; 23(5): 423-432, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29768954
16.
Evaluation of Evolocumab (AMG 145), a Fully Human Anti-PCSK9 IgG2 Monoclonal Antibody, in Subjects With Hepatic Impairment.
J Clin Pharmacol
; 57(4): 513-523, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27667740
17.
Impact of Target-Mediated Elimination on the Dose and Regimen of Evolocumab, a Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9).
J Clin Pharmacol
; 57(5): 616-626, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27861991
18.
SRM-based measurements of proprotein convertase subtilisin/kexin type 9 and lipoprotein(a) kinetics in nonhuman primate serum.
Bioanalysis
; 8(24): 2551-2563, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27884075
19.
Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.
J Am Coll Cardiol
; 60(19): 1888-98, 2012 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23083772
20.
Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.
ACS Med Chem Lett
; 2(11): 824-7, 2011 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900270