Pesquisa | Biblioteca Virtual em Saúde

1.

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module.

Arce, Nicholas A; Markham-Lee, Zoe; Liang, Qian; Najmudin, Shabir; Legan, Emily R; Dean, Gabrielle; Su, Ally J; Wilson, Moriah S; Sidonio, Robert F; Lollar, Pete; Emsley, Jonas; Li, Renhao.

Blood ; 143(19): 1992-2004, 2024 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-38290109

2.

Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity.

Maurer, Sigrun K; Mayer, Matthias P; Ward, Stephanie J; Boudjema, Sana; Halawa, Mohamed; Zhang, Jiatong; Caulton, Simon G; Emsley, Jonas; Dreveny, Ingrid.

J Biol Chem ; 299(11): 105300, 2023 11.

Artigo em Inglês | MEDLINE | ID: mdl-37777157

3.

Plasma Kallikrein as a Forgotten Clotting Factor.

Kearney, Katherine J; Spronk, Henri M H; Emsley, Jonas; Key, Nigel S; Philippou, Helen.

Semin Thromb Hemost ; 2023 Apr 18.

Artigo em Inglês | MEDLINE | ID: mdl-37072020

4.

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer.

Slater, Alexandre; Di, Ying; Clark, Joanne C; Jooss, Natalie J; Martin, Eleyna M; Alenazy, Fawaz; Thomas, Mark R; Ariëns, Robert A S; Herr, Andrew B; Poulter, Natalie S; Emsley, Jonas; Watson, Steve P.

Blood ; 137(24): 3443-3453, 2021 06 17.

Artigo em Inglês | MEDLINE | ID: mdl-33512486

5.

Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update.

Markham-Lee, Zoe; Morgan, Neil V; Emsley, Jonas.

Platelets ; 34(1): 2138306, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-36281781

6.

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.

Kaira, Bubacarr G; Slater, Alexandre; McCrae, Keith R; Dreveny, Ingrid; Sumya, Ummay; Mutch, Nicola J; Searle, Mark; Emsley, Jonas.

Blood ; 136(14): 1685-1697, 2020 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-32559765

7.

Exosites expedite blood coagulation.

Oliva, Maria Luiza Vilela; Dreveny, Ingrid; Emsley, Jonas.

J Biol Chem ; 295(45): 15208-15209, 2020 11 06.

Artigo em Inglês | MEDLINE | ID: mdl-33158918

8.

Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor.

Ribeiro, Jean F R; Cianni, Lorenzo; Li, Chan; Warwick, Thomas G; de Vita, Daniela; Rosini, Fabiana; Dos Reis Rocho, Fernanda; Martins, Felipe C P; Kenny, Peter W; Lameira, Jeronimo; Leitão, Andrei; Emsley, Jonas; Montanari, Carlos A.

Bioorg Med Chem ; 28(22): 115743, 2020 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-33038787

9.

The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.

Ward, Stephanie J; Gratton, Hayley E; Indrayudha, Peni; Michavila, Camille; Mukhopadhyay, Rishov; Maurer, Sigrun K; Caulton, Simon G; Emsley, Jonas; Dreveny, Ingrid.

J Biol Chem ; 293(45): 17362-17374, 2018 11 09.

Artigo em Inglês | MEDLINE | ID: mdl-30228188

10.

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation.

Ivanov, Ivan; Matafonov, Anton; Sun, Mao-Fu; Cheng, Qiufang; Dickeson, S Kent; Verhamme, Ingrid M; Emsley, Jonas; Gailani, David.

Blood ; 129(11): 1527-1537, 2017 03 16.

Artigo em Inglês | MEDLINE | ID: mdl-28069606

11.

Improving the understanding of plasma kallikrein contribution to arterial thrombus formation using two plant protease inhibitors.

Salu, Bruno R; Pando, Silvana Cristina; Brito, Marlon V De; Medina, André Fernando; Odei-Addo, Frank; Frost, Carminita; Naude, Ryno; Sampaio, Misako U; Emsley, Jonas; Maffei, Francisco Humberto A; Oliva, Maria Luiza V.

Platelets ; 30(3): 305-313, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-29442535

12.

Factor VIII/VWF complex caught on camera.

Xu, Emma-Ruoqi; Emsley, Jonas.

Blood ; 137(21): 2865-2866, 2021 05 27.

Artigo em Inglês | MEDLINE | ID: mdl-34042981

13.

A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.

Wong, Szu S; Østergaard, Søren; Hall, Gareth; Li, Chan; Williams, Philip M; Stennicke, Henning; Emsley, Jonas.

Blood ; 127(23): 2915-23, 2016 06 09.

Artigo em Inglês | MEDLINE | ID: mdl-27006387

14.

PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal: CRYSTAL STRUCTURE, INHIBITION, AND REACTION MECHANISM.

Drees, Steffen Lorenz; Li, Chan; Prasetya, Fajar; Saleem, Muhammad; Dreveny, Ingrid; Williams, Paul; Hennecke, Ulrich; Emsley, Jonas; Fetzner, Susanne.

J Biol Chem ; 291(13): 6610-24, 2016 Mar 25.

Artigo em Inglês | MEDLINE | ID: mdl-26811339

15.

Plasma kallikrein's low gear.

Emsley, Jonas.

Blood ; 135(8): 518-519, 2020 02 20.

Artigo em Inglês | MEDLINE | ID: mdl-32078685

16.

Exploiting the kinetic interplay between GPIbα-VWF binding interfaces to regulate hemostasis and thrombosis.

Chen, Jianchung; Zhou, Hairu; Diacovo, Alexander; Zheng, X Long; Emsley, Jonas; Diacovo, Thomas G.

Blood ; 124(25): 3799-807, 2014 Dec 11.

Artigo em Inglês | MEDLINE | ID: mdl-25293780

17.

Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR).

Ilangovan, Aravindan; Fletcher, Matthew; Rampioni, Giordano; Pustelny, Christian; Rumbaugh, Kendra; Heeb, Stephan; Cámara, Miguel; Truman, Alex; Chhabra, Siri Ram; Emsley, Jonas; Williams, Paul.

PLoS Pathog ; 9(7): e1003508, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23935486

18.

VWF (von Willebrand Factor) Comes in From the Cold As a Strategy to Improve Platelet Storage.

Emsley, Jonas.

Arterioscler Thromb Vasc Biol ; 39(10): 1893-1895, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31553666

19.

Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1.

Edwards, John M; Long, Jed; de Moor, Cornelia H; Emsley, Jonas; Searle, Mark S.

Nucleic Acids Res ; 41(14): 7153-66, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23748565

20.

Structure and catalytic regulatory function of ubiquitin specific protease 11 N-terminal and ubiquitin-like domains.

Harper, Stephen; Gratton, Hayley E; Cornaciu, Irina; Oberer, Monika; Scott, David J; Emsley, Jonas; Dreveny, Ingrid.

Biochemistry ; 53(18): 2966-78, 2014 May 13.

Artigo em Inglês | MEDLINE | ID: mdl-24724799

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