Detalhe da pesquisa
1.
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
J Med Chem
; 65(1): 409-423, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34910486
2.
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.
Nat Commun
; 13(1): 5992, 2022 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36220877
3.
Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.
ChemMedChem
; 13(7): 672-677, 2018 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29399991
4.
Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis.
J Med Chem
; 61(24): 11327-11340, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30457865
5.
A new 'golden age' for the antitubercular target InhA.
Drug Discov Today
; 22(3): 492-502, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27663094
6.
New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
Eur J Med Chem
; 112: 252-257, 2016 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26900657
7.
THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.
Nat Microbiol
; 1: 15006, 2016 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571973
8.
Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.
EBioMedicine
; 8: 291-301, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-27428438
9.
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis.
J Med Chem
; 58(2): 613-24, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25517015
10.
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA.
J Med Chem
; 57(4): 1276-88, 2014 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24450589
11.
Polymer-assisted solution-phase synthesis of glycosyl chlorides and bromides using a supported dialkylformamide as catalyst.
J Comb Chem
; 10(3): 361-3, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18351747