Detalhe da pesquisa
1.
Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies.
Am J Hum Genet
; 86(5): 749-64, 2010 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20466091
2.
DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome.
Am J Hum Genet
; 83(3): 388-400, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18771760
3.
Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome.
Cereb Cortex
; 20(5): 1131-43, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19710359
4.
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Neuron
; 51(1): 29-42, 2006 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16815330
5.
Increased lipid peroxidation in Down's syndrome mouse models.
J Neurochem
; 110(6): 1965-76, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19645748
6.
2010 Victor A. McKusick Leadership Award introduction and address.
Am J Hum Genet
; 88(3): 269-72, 2011 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21516616
7.
Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates.
Toxicol Appl Pharmacol
; 234(3): 326-38, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19063909
8.
Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.
Neuron
; 33(2): 219-32, 2002 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-11804570
9.
The in vivo gene expression signature of oxidative stress.
Physiol Genomics
; 34(1): 112-26, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18445702
10.
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.
J Comp Neurol
; 504(4): 329-45, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17663443
11.
The challenge of Down syndrome.
Trends Mol Med
; 12(10): 473-9, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16935027
12.
Down's syndrome: critical genes in a critical region.
Nature
; 441(7093): 582-3, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16738647
13.
A mechanism-based antioxidant approach for the reduction of skin carcinogenesis.
Cancer Res
; 65(4): 1401-5, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15735027
14.
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.
Oncogene
; 24(3): 367-80, 2005 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15531919
15.
Effect of the reduction of superoxide dismutase 1 and 2 or treatment with alpha-tocopherol on tumorigenesis in Atm-deficient mice.
Free Radic Biol Med
; 41(4): 590-600, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16863992
16.
Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy.
Free Radic Biol Med
; 40(11): 1993-2004, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16716900
17.
Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging.
Mech Ageing Dev
; 127(3): 298-306, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16405961
18.
Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model.
Oncogene
; 21(24): 3836-46, 2002 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12032821
19.
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
J Neurosci
; 24(37): 8153-60, 2004 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15371516
20.
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.
J Neurosci
; 23(17): 6788-92, 2003 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12890772