Pinkus tumor at the nostril floor.

Fibroepithelioma of Pinkus is a variant form of basal cell carcinoma that clinically presents as a single or multiple red plaques or flesh-colored nodules without ulceration. It is usually located in the trunk, inguinal, or crural areas and only rarely occurs on the mucocutaneous junction. A 70-year-old female patient presented with a mass at the left nostril, which had first appeared about 1 year earlier. A single nontender red lesion was about 1 cm, and its base was on the mucocutaneous junction at the floor of the left nostril. Wide local excision was carried out with an adequate resection margin (5 mm) under local anesthesia. Microscopic examination showed tumoral pathologic sections of skin tissue fragments were observed; tumoral structure into the stroma is composed of proliferating basaloid cells (forming an interanastomosing pattern); around the tumor islands is rimming palisade, and infiltration of mononuclear cells around the tumor is moderate. The specimen exhibited no atypia, and the margin of excised mass was clear. The patient is being monitored for any possible local recurrence.

Neurofibromas of the bladder in a child with neurofibromatosis type 1 causing chronic renal disease.

Neurofibromatosis type 1 (NF1) is an autosomal-dominant inherited disorder and its prominent feature is the neurofibroma and renal involvement includes renal artery stenosis and renal artery aneurysms causing renovascular hypertension. The genitourinary tract may be rarely involved, leading to urinary symptoms of obstruction and hydronephrosis. Herein, we report a 12-year-old boy with chronic renal failure associated with neurofibromas of the bladder, which leads to urinary obstruction.

Is Positive Staining of Non-Functioning Pituitary Adenomas for Luteinizing Hormone Associated with a Poor Prognosis?

AIM: The aim of this study was to assess the relationships among immunohistochemical staining patterns and prognostic factors in patients with non-functioning pituitary adenoma (NFPA). MATERIAL AND METHODS: The study included 103 patients who had undergone pituitary surgery for NFPAs. The prognostic factors evaluated were initial tumor size, cavernous sinus invasion, compression of the optic chiasm, recurrence, residual tissue, reoperation, and hypopituitarism. RESULTS: Recurrence rates were higher for NFPAs with large initial tumor volume and preoperative cavernous sinus invasion. Tumor recurrence rates were higher for NPFAs positive (55.6%) than negative (10.3%) for luteinizing hormone (LH). Reoperation rate, but not recurrence rate, was higher in patients with tumors positive than negative for follicle-stimulating hormone (FSH) group. Recurrence and reoperation rates were lowest in patients with null-cell adenomas. CONCLUSION: In contrast to previous studies, we observed a higher recurrence rate in LH-positive than in LH-negative adenomas. To our knowledge, this is the first study showing an association between LH positivity and poorer prognosis; and in addition, optimal outcomes in patients with null-cell adenomas. Thus, additional studies are required to assess the relationship between LH positivity and poor prognosis in patients with NFPAs.