Safety and Efficacy of Prolonged Use of Dalbavancin in Bone and Joint Infections.

Dalbavancin is a lipoglycopeptide with potent activity against Gram-positive microorganisms, a long half-life, a favorable safety profile, and a high concentration in bone, which makes it an interesting alternative for treatment of osteoarticular infections. We performed a multicentric retrospective study of all patients with an osteoarticular infection (septic arthritis, spondylodiscitis, osteomyelitis, or orthopedic implant-related infection) treated with at least one dose of dalbavancin between 2016 and 2017 in 30 institutions in Spain. In order to evaluate the response, patients with or without an orthopedic implant were separated. A total of 64 patients were included. Staphylococcus epidermidis and Staphylococcus aureus were the most frequent microorganisms. The reasons for switching to dalbavancin were simplification (53.1%), adverse events (25%), or failure (21.9%). There were 7 adverse events, and no patient had to discontinue dalbavancin. In 45 cases, infection was related to an orthopedic implant. The implant material was retained in 23 cases, including that in 15 (65.2%) patients that were classified as cured and 8 (34.8%) that presented improvement. In 21 cases, the implants were removed, including those in 16 (76.2%) cases that were considered successes, 4 (19%) cases were considered improved, and 1 (4.8%) case that was considered a failure. Among the 19 cases without implants, 14 (73.7%) were considered cured, 3 (15.8%) were considered improved, and 2 (10.5%) were considered failures. The results show that dalbavancin is a well-tolerated antibiotic, even when >2 doses are administered, and is associated with a high cure rate. These are preliminary data with a short follow-up; therefore, it is necessary to gain more experience and, in the future, to establish the most appropriate dose and frequency.

[Q fever: 54 new cases from a tertiary hospital in Madrid]. / Fiebre Q: 54 nuevos casos de un hospital terciario de Madrid.

OBJECTIVES: To describe the epidemiological and clinical characteristics of Q fever in an urban zone of the Community of Madrid (Spain). MATERIAL AND METHODS: An observational, retrospective study was performed of a cohort of cases diagnosed of Q fever within a single center in Madrid from January 2001 to December 2008. The diagnosis of acute Q fever was made by detection of antibodies against phase II antigen by Enzyme-Linked Immunosorbent Assay (ELISA) and indirect immunofluorescence (IFA), based on isolated titer ≥ 1/80 or when they showed seroconversion or seroreinforcement. Chronic Q fever was diagnosed using antibodies against phase I with a positive value if IgG ≥ 1/800. RESULTS: A total of 54 cases of Q fever in adults were diagnosed; 51 patients had acute Q fever and only 3 chronic. There was a predominance of men over > 50 years and from urban areas. The most frequent manifestation was pneumonia (54%), followed by renal failure (33%), hepatitis and fever without focality (25% in both), with concomitant infection in 37% of the cases. The clinical and serological monitoring in most of the patients were inadequate. The best response to treatment was with doxycycline in acute illness, although duration was inadequate in 10%.

[Periodic familial fever]. / Fiebre periódica hereditaria.

The familial periodic fevers are Known as autoinflammatory syndromes. It is important in clinical practice to recognize these uncommon illnesses characterized by recurrent bouts of unspecific systemic symptoms associated to elevation of acute phase reactants without autoantibodies or underlying infection. The clinical suspicion supported on the molecular diagnosis represents a new perspective in relation to treatment and prognosis of these patients.

[Crohn s disease: is still the reason of fever of unknown origin?]. / Enfermedad de Crohn: ¿todavía hoy causa de fiebre de origen desconocido clásica?

We present two patients with Crohn's disease who presented with fever unknown origin, and mild intestinal symptoms. In case 1, the debut was with intermittent fever and symmetrical polyarthritis of the wrists, elbows, ankles and knees; in the case 2, prolonged fever associated to unspecific colicky abdominal pain. The initial approach was fever unknown origin yielded no etiology in both of them. The barium studies of the intestinal tract of paramount importance to reach a positive diagnosis in both cases. We strongly recommend the use of barium studies as a first line diagnostic tool in the approach of fever unknown origin.

Organización de la cuarentena hospitalaria en los evacuados de Wuhan al inicio de la pandemia de COVID-19 / Hospital organization quarantine in Wuhan evacuees at the start of the COVID-19 pandemic

INTRODUCCIÓN: El 31 de diciembre de 2019, la Organización Mundial de la Salud fue informada de un grupo de casos de neumonía de etiología desconocida detectados en la ciudad de Wuhan (China). El 30 de enero de 2020, se declaró el brote de nCoV-2019 (posteriormente SARS-CoV-2) como una emergencia de salud pública de preocupación internacional. En este contexto, algunos países occidentales, decidieron evacuar a sus ciudadanos. OBJETIVOS: En este artículo se describe el planteamiento llevado a cabo en el caso de las personas evacuadas desde Wuhan a su llegada a España. MATERIAL Y MÉTODO: Se recopiló información sobre los criterios para seleccionar las instalaciones y el personal, el número de casos en cuarentena, la estrategia de control de infección, la duración de la cuarentena, la monitorización clínica y otros aspectos relevantes. RESULTADOS: Las autoridades sanitarias españolas seleccionaron el Hospital Central de Defensa Gómez Ulla para realizar una cuarentena hospitalaria. Veintiuna personas fueron trasladadas de Wuhan a Madrid, incluidos dos niños. Los médicos de medicina preventiva y enfermedades infecciosas fueron seleccionados para dirigir y asistir la vigilancia. Las visitas fueron autorizadas siguiendo un protocolo establecido. CONCLUSIONES: Este es el primer informe sobre cuarentena hospitalaria para SARS-CoV-2, diseñado específicamente para repatriados. La cuarentena hospitalaria podría ser un método útil para casos seleccionados de enfermedades altamente contagiosas. Sin embargo, se necesita un buen soporte de recursos e instalaciones, selección de personal experimentado y protocolos revisados

INTRODUCTION: On December 31, 2019, the World Health Organization was informed of a group of cases of pneumonia of unknown etiology detected in the city of Wuhan (China). On January 30, 2020, the nCoV-2019 outbreak (later SARS-CoV-2) was declared a public health emergency of international concern. In this context, some western countries decided to evacuate their citizens. AIM: This article describes the approach taken in the case of people evacuated from Wuhan upon arrival in Spain. METHODS: Information was collected on the criteria for selecting facilities and personnel, the number of quarantine cases, the infection control strategy, the duration of quarantine, clinical monitoring, and other relevant aspects. RESULTS: The Spanish health authorities selected the Gómez Ulla Central Defense Hospital to carry out a hospital quarantine. Twenty-one people were transferred from Wuhan to Madrid, including two children. Preventive medicine and infectious disease physicians were selected to direct and assist surveillance. The visits were authorized following an established protocol. CONCLUSIONS: This is the first hospital quarantine report for SARS-CoV-2, designed specifically for returnees. Hospitalarian quarantine could be a useful method for selected cases of highly contagious diseases. However, good resource and facility support, selection of experienced staff, and revised protocols are required

Síndrome de Lemierre. Reporte de un caso con embolismos sépticos pulmonar y muscular y revisión de la literatura / Lemierre's syndrome. Report of a case with pulmonary and muscular septic embolisms and literature review

El síndrome de Lemierre es una complicación rara pero mortal de las infecciones orofaríngeas definido por tromboflebitis de la vena yugular interna que origina embolismos sépticos a múltiples localizaciones entre las que destacan por su mayor frecuencia los pulmones. Presentamos el caso de un varón de 19 años previamente sano en el que se objetivaron metástasis sépticas en ambos pulmones y músculo pectoral mayor derecho. Según nuestro conocimiento este es el primer reporte de un síndrome de Lemierre causante de embolismo séptico pectoral. La revisión de la literatura aporta información sobre cómo realizar el diagnóstico de sospecha de esta entidad y el tratamiento empírico adecuado

Lemierre's syndrome is a strange but potentially deadly complication or oropharyngeal infections defined by internal jugular vein thrombosis that originates septic embolisms towards various locations among which the lungs stands out because of its frequency. We report the case of a 19 years old previously healthy male who was diagnosed with septic methastaes in both lungs and in the right major pectoral muscle. As far as we are concerned this is the first report of a Lemierre's syndrome causing a pectoral septic embolism. Literature review delivers information on how to diagnose this entity and the adequate empiric treatment

[The spectrum of familial Mediterranean fever]. / El espectro de la fiebre mediterránea familiar.

Familial mediterranean fever (FMF) is a disease whose importance in recent years is reappearing thanks to the advances in molecular genetics. The diagnosis is established by symptoms, presence of inflammatory episodes of fever and serositis, family background and genetic study. Identification of the most prevalent mutations of the MEFV gene may confirm atypical or incomplete forms of FMS that are difficult to recognize based on the classical major and minor criteria. Knowledge of this more extensive clinical spectrum makes it possible to have a new diagnostic and therapeutic perspective based on the treatment of colchicine and secondary prevention of AA amyloidosis.

The role of endothelial progenitor cells and statins in endothelial function: a review.

Endothelial dysfunction, a well recognized marker of cardiovascular risk, is an early event in arteriosclerosis process. Diabetes mellitus, hypertension and dyslipidemia, known risk factors for coronary disease have been associated with endothelial dysfunction, which improves after the control of these factors. Statins have additional benefits on endothelial function not related to decreasing cholesterol levels, known as pleiotropic effects. Most recently it has been reported the effect of statins promoting bone marrow-derived mononuclear cells. These cells are positive for CD34 and KDR superficial markers of endothelial cellular lineage, which is consistent with the hypothesis that they constitute the endothelial progenitor cells. Circulating endothelial progenitor cells are involved in the repair process of the endothelium after endothelial-cell injury in myocardial ischemia, angina and other stressful situations. Recent studies have demonstrated an inverse relationship between the EPC count in peripheral blood and risk of developing a cardiovascular event. In addition, circulating EPC correlates with the presence of endothelial dysfunction and could play a role as a surrogate biologic marker in vascular function. The effect of statins on endothelial progenitor cells might contribute to improve endothelial function leading to a decrease in vascular risk, independently of their impact on LDL cholesterol. In this paper, we review the role of statins in EPC mobilization, its effect in endothelial function restoration and the relevance of this finding in cardiovascular risk. We also review future therapeutic implications.

Fiebre Q: 54 nuevos casos de un hospital terciario de Madrid / Q fever: 54 new cases from a tertiary hospital in Madrid

Objetivos. Describir las características epidemiológicas y clínicas de la fiebre Q en una zona urbana de la Comunidad de Madrid. Material y métodos. Estudio observacional retrospectivo de cohorte de los casos diagnosticados de fiebre Q en un único centro desde enero de 2001 hasta diciembre de 2008. El diagnóstico de fiebre Q aguda se realizó mediante la detección de anticuerpos frente a antígenos fase II por técnica de enzyme-linked immunosorbent assay (ELISA) e inmunofluorescencia indirecta (IFI), en base a un título aislado ≥ 1/80 o cuando se demostró seroconversión o serorrefuerzo. El de fiebre Q crónica se realizó mediante anticuerpos frente antígenos fase I positivo si IgG >= 1/800. Resultados. Se diagnosticaron 54 casos de fiebre Q en adultos. Cincuenta y un pacientes con fiebre Q aguda y 3 con fiebre Q crónica. Predominaron los varones de más de 50 años de edad y residentes en medio urbano. La clínica más frecuente fue la neumonía, la insuficiencia renal (33%), la hepatitis y el síndrome febril sin focalidad (25% ambas), con infección concomitante en el 37% de los casos. El seguimiento clínico y serológico en la mayoría de los pacientes fue inadecuado. La doxiciclina fue el tratamiento de mayor respuesta en enfermedad aguda, aunque en 10% con duración inadecuada(AU)

Objectives. To describe the epidemiological and clinical characteristics of Q fever in an urban zone of the Community of Madrid (Spain). Material and methods. An observational, retrospective study was performed of a cohort of cases diagnosed of Q fever within a single center in Madrid from January 2001 to December 2008. The diagnosis of acute Q fever was made by detection of antibodies against phase II antigen by Enzyme-Linked Immunosorbent Assay (ELISA) and indirect immunofluorescence (IFA), based on isolated titer ≥ 1/80 or when they showed seroconversion or seroreinforcement. Chronic Q fever was diagnosed using antibodies against phase I with a positive value if IgG >= 1/800. Results. A total of 54 cases of Q fever in adults were diagnosed; 51 patients had acute Q fever and only 3 chronic. There was a predominance of men over > 50years and from urban areas. The most frequent manifestation was pneumonia (54%), followed by renal failure (33%), hepatitis and fever without focality (25% in both), with concomitant infection in 37% of the cases. The clinical and serological monitoring in most of the patients were inadequate. The best response to treatment was with doxycycline in acute illness, although duration was inadequate in 10%(AU)

Fiebre facticia: una enfermedad sin diagnóstico de imagen / No disponible

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Fiebre periódica hereditaria / Periodic fever familial

Las enfermedades que se incluyen dentro del grupo de fiebres periódicas hereditarias forman parte del nuevo concepto de fenómeno “autoinflamatorio”.El conocimiento de esta entidad permite reconocer en la práctica clínica este grupo de enfermedades infrecuentes que se caracterizan por manifestaciones sistémicas inespecíficas recurrentes asociadas a elevación de reactantes de fase aguda con estudio de autoinmunidad negativo y sin evidencia de infección subyacente. La sospecha clínica apoyada en los avances de las técnicas de diagnóstico molecular permite dar al paciente una nueva perspectiva en cuanto al pronóstico y tratamiento

The familial periodic fevers are Known as autoinflammatory syndromes. It is important in clinical practice to recognize these uncommon illnesses characterized by recurrent bouts of unspecific systemic symptoms associated to elevation of acute phase reactants without autoantibodies or underlying infection. The clinical suspicion supported on the molecular diagnosis represents a new perspective in relation to treatment and prognosis of these patients

El espectro de la fiebre mediterránea familiar / The spectrum of familial mediterranean fever

La fiebre mediterránea familiar (FMF) es una enfermedad cuyo protagonismo en los últimos años está resurgiendo gracias a los avances en genética molecular. El diagnóstico se establece por la clínica, presencia de accesos inflamatorios de fiebre y serositis, antecedentes familiares y estudio genético. La identificación de las mutaciones más prevalentes del gen MEFV permite confirmar formas atípicas o incompletas de FMF, que difícilmente podrían ser reconocidas basándonos en los criterios mayores y menores clásicos. El conocimiento de este espectro clínico más amplio, permite dar una nueva perspectiva diagnóstica y terapéutica basada en el tratamiento con colchicina y prevención secundaria de la amiloidosis AA (AU)

Familial mediterranean fever (FMF) is a disease whose importance in recent years is reappearing thanks to the advances in molecular genetics. The diagnosis is established by symptoms, presence of inflammatory episodes of fever and serositis, family background and genetic study. Identification of the most prevalent mutations of the MEFV gene may confirm atypical or incomplete forms of FMS that are difficult to recognize based on the classical major and minor criteria. Knowledge of this more extensive clinical spectrum makes it possible to have a new diagnostic and therapeutic perspective based on the treatment of colchicine and secondary prevention of AA amyloidosis (AU)

Anemia regenerativa y mielofibrosis / Regenerative anemia and myelofibrosis

No disponible