Detalhe da pesquisa
1.
Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat Chem Biol
; 20(2): 162-169, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37537379
2.
Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features.
Biol Chem
; 2024 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38373142
3.
Self-Assembly of Exendin-4-Derived Dual Peptide Agonists is Mediated by Acylation and Correlated to the Length of Conjugated Fatty Acyl Chains.
Mol Pharm
; 17(3): 965-978, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31968941
4.
Incretin combination therapy for the treatment of non-alcoholic steatohepatitis.
Diabetes Obes Metab
; 22(8): 1328-1338, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32196896
5.
Running on mixed fuel-dual agonistic approach of GLP-1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non-human primates.
Diabetes Obes Metab
; 20(8): 1836-1851, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29938884
6.
Modulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5.
Chembiochem
; 17(9): 861-5, 2016 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26812365
7.
Engineering hydrophobicity and manufacturability for optimized biparatopic antibody-drug conjugates targeting c-MET.
MAbs
; 16(1): 2302386, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38214660
8.
Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers.
MAbs
; 16(1): 2315640, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38372053
9.
Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity.
Bioorg Med Chem Lett
; 23(14): 4011-8, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23743288
10.
SUMO: In Silico Sequence Assessment Using Multiple Optimization Parameters.
Methods Mol Biol
; 2681: 383-398, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37405660
11.
Cattle-derived knob paratopes grafted onto peripheral loops of the IgG1 Fc region enable the generation of a novel symmetric bispecific antibody format.
Front Immunol
; 14: 1238313, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37942319
12.
A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization.
MAbs
; 15(1): 2261149, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37766540
13.
NKp46-specific single domain antibodies enable facile engineering of various potent NK cell engager formats.
Protein Sci
; 32(3): e4593, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36775946
14.
Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition.
MAbs
; 15(1): 2236265, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37469014
15.
AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study.
Front Mol Biosci
; 10: 1249247, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37842638
16.
Selective non-lipid modulator of LPA5 activity in human platelets.
Bioorg Med Chem Lett
; 22(16): 5239-43, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22801643
17.
MARS: computing three-dimensional alignments for multiple ligands using pairwise similarities.
J Chem Inf Model
; 52(8): 2022-30, 2012 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22794356
18.
Long-Term Stability Prediction for Developability Assessment of Biopharmaceutics Using Advanced Kinetic Modeling.
Pharmaceutics
; 14(2)2022 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35214107
19.
Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities.
MAbs
; 14(1): 2018960, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35014603
20.
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
Cell Metab
; 34(1): 59-74.e10, 2022 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34932984