Detalhe da pesquisa
1.
In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.
J Pharmacol Exp Ther
; 330(1): 257-67, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19389923
2.
Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity.
Biochem Pharmacol
; 73(8): 1243-55, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17371699
3.
Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand.
Br J Pharmacol
; 148(5): 657-70, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16715122
4.
Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency.
J Med Chem
; 48(20): 6482-90, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190774
5.
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.
J Med Chem
; 48(1): 38-55, 2005 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15634000
6.
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs.
Brain Res
; 1045(1-2): 142-9, 2005 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-15910772
7.
Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist.
Biochem Pharmacol
; 68(5): 933-45, 2004 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15294456
8.
Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists.
Mini Rev Med Chem
; 4(9): 979-92, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15544558
9.
Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.
Behav Brain Res
; 131(1-2): 151-61, 2002 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11844582
10.
Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist.
Eur J Pharmacol
; 487(1-3): 183-97, 2004 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15033391
11.
Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model.
Pharmacol Biochem Behav
; 72(3): 741-50, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12175472
12.
In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
Basic Clin Pharmacol Toxicol
; 95(3): 144-52, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15447739
13.
Allosteric modulators of the alpha7 nicotinic acetylcholine receptor.
J Med Chem
; 51(4): 701-12, 2008 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18198823
14.
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.
J Med Chem
; 52(10): 3377-84, 2009 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19419141
15.
Advances in the discovery of novel positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor.
Recent Pat CNS Drug Discov
; 2(2): 99-106, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18221220
16.
Structure-activity relationships of arylbenzofuran H3 receptor antagonists.
Bioorg Med Chem Lett
; 15(10): 2559-63, 2005 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15863316
17.
Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist.
J Pharmacol Exp Ther
; 313(1): 176-90, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15608077
18.
Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Bioorg Med Chem Lett
; 12(21): 3077-9, 2002 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12372505
19.
Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization.
J Pharmacol Exp Ther
; 305(3): 897-908, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12606600
20.
Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects.
J Pharmacol Exp Ther
; 305(3): 887-96, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12606603