Detalhe da pesquisa
1.
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
J Biol Chem
; 294(26): 10194-10210, 2019 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092554
2.
Traffic jam at the nuclear pore: All roads lead to nucleocytoplasmic transport defects in ALS/FTD.
Neurobiol Dis
; 140: 104835, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32179176
3.
A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants.
Hum Mol Genet
; 26(11): 2146-2155, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28379367
4.
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.
Nature
; 488(7412): 499-503, 2012 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22801503
5.
Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons.
J Neurosci
; 36(13): 3811-20, 2016 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27030765
6.
The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.
Hum Mol Genet
; 21(16): 3703-18, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22641816
7.
LINC complex alterations are a hallmark of sporadic and familial ALS/FTD.
bioRxiv
; 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38559165
8.
LINC complex alterations are a key feature of sporadic and familial ALS/FTD.
Acta Neuropathol Commun
; 12(1): 69, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38664831
9.
Altered nuclear envelope homeostasis is a key pathogenic event in C9ORF72-linked ALS/FTD.
bioRxiv
; 2024 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38352403
10.
The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons.
J Neurosci
; 31(10): 3914-25, 2011 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21389246
11.
ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function.
Cell Rep
; 39(1): 110598, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385738
12.
Novel TUBA4A Variant Associated With Familial Frontotemporal Dementia.
Neurol Genet
; 7(3): e596, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34169147
13.
Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis.
JAMA Neurol
; 78(10): 1236-1248, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34459874
14.
TDP-43 is recruited to stress granules in conditions of oxidative insult.
J Neurochem
; 111(4): 1051-61, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19765185
15.
TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene.
Biochim Biophys Acta Gene Regul Mech
; 1862(9): 194413, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31382054
16.
Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis.
Nat Commun
; 10(1): 3827, 2019 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31444357
17.
The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability.
BMC Mol Biol
; 8: 111, 2007 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-18053171
18.
The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly.
Cell Rep
; 18(7): 1660-1673, 2017 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28199839
19.
ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.
Sci Rep
; 7(1): 115, 2017 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28273913
20.
Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.
Sci Transl Med
; 9(388)2017 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28469040