Detalhe da pesquisa
1.
Computational Model of In Vivo Corneal Pharmacokinetics and Pharmacodynamics of Topically Administered Ophthalmic Drug Products.
Pharm Res
; 40(4): 961-975, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36959411
2.
Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating Patients With Coronavirus Disease 2019.
Clin Infect Dis
; 71(12): 3232-3236, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435791
3.
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions.
Mol Pharm
; 15(12): 5454-5467, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30372084
4.
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.
Mol Pharm
; 15(12): 5468-5478, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30417648
5.
A Multiscale Physiologically-Based Pharmacokinetic Model for Doxorubicin to Explore its Mechanisms of Cytotoxicity and Cardiotoxicity in Human Physiological Contexts.
Pharm Res
; 35(9): 174, 2018 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29987398
6.
Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs.
Mol Pharm
; 14(12): 4281-4294, 2017 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28737409
7.
Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo.
Drug Metab Dispos
; 44(7): 1123-38, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27098743
8.
Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.
Gastroenterology
; 146(4): 1048-59, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24365583
9.
Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.
Pharm Res
; 32(3): 1128-40, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25319098
10.
US Food and Drug Administration Approval Summary: Elacestrant for Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative, ESR1-Mutated Advanced or Metastatic Breast Cancer.
J Clin Oncol
; 42(10): 1193-1201, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38381994
11.
[Development of ultrasound-based monitor of relative blood volume].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
; 30(6): 1204-8, 2013 Dec.
Artigo
em Zh
| MEDLINE | ID: mdl-24645597
12.
Regulatory utility of physiologically-based pharmacokinetic modeling to support alternative bioequivalence approaches and risk assessment: A workshop summary report.
CPT Pharmacometrics Syst Pharmacol
; 12(5): 585-597, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36530026
13.
FDA Approval Summary: Futibatinib for Unresectable Advanced or Metastatic, Chemotherapy Refractory Intrahepatic Cholangiocarcinoma with FGFR2 Fusions or Other Rearrangements.
Clin Cancer Res
; 29(20): 4027-4031, 2023 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37289037
14.
Extent of extracellular signal-regulated kinases phosphorylation determines the sensitivity of hepatic stellate cells to staurosporine-induced apoptosis.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 37(1): 11-6, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22349387
15.
Whole Body PBPK Modeling of Remdesivir and Its Metabolites to Aid in Estimating Active Metabolite Exposure in the Lung and Liver in Patients With Organ Dysfunction.
Clin Pharmacol Ther
; 111(3): 624-634, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34656075
16.
Model-Informed Drug Development Approaches to Assist New Drug Development in the COVID-19 Pandemic.
Clin Pharmacol Ther
; 111(3): 572-578, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34807992
17.
Pharmacokinetics, tissue distribution, and excretion of buagafuran in rats.
J Asian Nat Prod Res
; 13(3): 205-14, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21409681
18.
How Science Is Driving Regulatory Guidances.
Methods Mol Biol
; 2342: 595-629, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34272707
19.
Usage of In Vitro Metabolism Data for Drug-Drug Interaction in Physiologically Based Pharmacokinetic Analysis Submissions to the US Food and Drug Administration.
J Clin Pharmacol
; 61(6): 782-788, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33460193
20.
Anti-SARS-CoV-2 Repurposing Drug Database: Clinical Pharmacology Considerations.
CPT Pharmacometrics Syst Pharmacol
; 10(9): 973-982, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34218521