Detalhe da pesquisa
1.
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Bioorg Med Chem Lett
; 89: 129277, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37105490
2.
Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species.
Drug Metab Dispos
; 50(3): 197-203, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34969659
3.
Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine.
Drug Metab Dispos
; 48(7): 528-536, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32350063
4.
Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human.
Mol Pharm
; 17(11): 4114-4124, 2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32955894
5.
Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.
Drug Metab Dispos
; 44(8): 1253-61, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27117704
6.
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.
Bioorg Med Chem Lett
; 24(13): 2877-80, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24825301
7.
Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver.
Xenobiotica
; 43(3): 236-45, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22931212
8.
Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.
Chem Res Toxicol
; 24(10): 1668-77, 2011 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21905702
9.
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
ACS Med Chem Lett
; 12(9): 1380-1388, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34527178
10.
Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction.
Drug Metab Dispos
; 38(5): 841-50, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20100816
11.
Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations.
J Pharm Sci
; 108(1): 109-119, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29909029
12.
Estimation of Fraction Dissolved After Intratracheal Delivery of a Potent Janus Kinase Inhibitor, iJAK-001, with Low Solubility in Rat and Sheep: Impact of Preclinical PKPD on Inhaled Human Dose Projection.
J Aerosol Med Pulm Drug Deliv
; 32(5): 251-265, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31084462
13.
Carboxylesterase catalyzed 18O-labeling of carboxylic acid and its potential application in LC-MS/MS based quantification of drug metabolites.
Drug Metab Pharmacokinet
; 34(5): 308-316, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235362
14.
NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.
Nat Commun
; 9(1): 179, 2018 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330524
15.
Elucidating the Mechanism of Tofacitinib Oxidative Decyanation.
Drug Metab Lett
; 10(2): 136-43, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27117606
16.
Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.
Drug Metab Lett
; 10(2): 91-100, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27063863
17.
Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System.
ACS Med Chem Lett
; 6(8): 925-9, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288695
18.
Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.
J Med Chem
; 58(12): 5121-36, 2015 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26030457
19.
Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery.
Future Med Chem
; 6(18): 1995-2012, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25531965
20.
Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance.
Drug Metab Dispos
; 30(6): 694-700, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12019197