Detalhe da pesquisa
1.
Research progress of PROTACs for neurodegenerative diseases therapy.
Bioorg Chem
; 147: 107386, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38643565
2.
Design, synthesis, and activity evaluation of novel multitargeted l-tryptophan derivatives with powerful antioxidant activity against Alzheimer's disease.
Arch Pharm (Weinheim)
; 357(5): e2300603, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38290060
3.
Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides.
J Am Chem Soc
; 145(41): 22639-22648, 2023 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37788450
4.
Dual functional antioxidant and butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of novel melatonin-alkylbenzylamine hybrids.
Bioorg Med Chem
; 78: 117146, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36580744
5.
Novel 2,6-disubstituted benzofuran-3-one analogues improve cerebral ischemia/reperfusion injury via neuroprotective and antioxidative effects.
Bioorg Chem
; 132: 106346, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36638655
6.
New compounds with hepatoprotective effects from the stems of Sabia parviflora.
J Asian Nat Prod Res
; 25(6): 547-556, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36036184
7.
Design, Synthesis and Anti-Tumor Activity Evaluation of Novel 3,4-(Methylenedioxy)cinnamic Acid Amide-Dithiocarbamate Derivatives.
Chem Biodivers
; 19(8): e202200439, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35703003
8.
Synthesis of Halogenated 1,5-Diarylimidazoles and Their Inhibitory Effects on LPS-Induced PGE2 Production in RAW 264.7 Cells.
Molecules
; 26(20)2021 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34684673
9.
Nanocrystal-Loaded Micelles for the Enhanced In Vivo Circulation of Docetaxel.
Molecules
; 26(15)2021 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34361634
10.
Design, synthesis and biological evaluation of coumarin-based N-hydroxycinnamamide derivatives as novel histone deacetylase inhibitors with anticancer activities.
Bioorg Chem
; 101: 104023, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32650178
11.
Design and synthesis of tetrahydropyridopyrimidine derivatives as dual GPR119 and DPP-4 modulators.
Bioorg Chem
; 94: 103390, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31662212
12.
Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-b][1,4]oxazine derivatives as potent GPR 119 agonists.
J Enzyme Inhib Med Chem
; 35(1): 50-58, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31656107
13.
Pristimerin attenuates cell proliferation of uveal melanoma cells by inhibiting insulin-like growth factor-1 receptor and its downstream pathways.
J Cell Mol Med
; 23(11): 7545-7553, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31508890
14.
Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists.
Bioorg Chem
; 86: 103-111, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30685641
15.
Design, Synthesis, and Biological Evaluation of Novel Thienopyrimidine Derivatives as PI3Kα Inhibitors.
Molecules
; 24(19)2019 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31547116
16.
Design and synthesis of novel senkyunolide analogues as neuroprotective agents.
Bioorg Med Chem Lett
; 28(4): 668-672, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29370975
17.
Design and synthesis of novel pyrimido[5,4-d]pyrimidine derivatives as GPR119 agonist for treatment of type 2 diabetes.
Bioorg Med Chem
; 26(14): 4080-4087, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30100020
18.
Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation.
Bioorg Chem
; 81: 512-528, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30245233
19.
Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist.
Bioorg Med Chem Lett
; 27(11): 2515-2519, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28408218
20.
Nitric oxide-donating derivatives of hederacolchiside A1: Synthesis and biological evaluation in vitro and in vivo as potential anticancer agents.
Bioorg Med Chem Lett
; 27(1): 98-101, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27866816