Photovoltaic panel waste assessment and embodied material flows in China, 2000-2050.

Solar photovoltaics (PV) is one of the most promising renewable energy sources for climate change mitigation. However, not all green energy installations may not continue to be sustainable after their service life. With the largest installed solar capacity in the world, China is expected to face significant challenges in managing the end-of-life (EoL) PV panels in the coming decades, which have not been well addressed yet.Further, the massive deployment and planning of solar energy systems in China has led to a dramatic increases in demand for raw materials, which places more pressure on the available resources. In this study, we have developed a dynamic, technology-based material flow analysis model to clarify the stock, flow and secondary supply potential of waste PV panel materials in China from 2000 to 2050. The waste generation and circular flow characteristics of the component materials in PV panels are comprehensively investigated, which set important boundary conditions for the recovery and recycling of key materials. The results show that approximately 134 million metric tons (Mt) and 72 Mt of waste PV panels will be cumulatively generated in China up to 2050 under the early loss and regular loss scenarios, respectively. Polysilicon glass accounts for the largest share of PV waste, nearly 64% by weight, followed by aluminum (16%) and steel (11%). Precious metals such as Ag, Ga, In, and Te, account for less than 1% of the total PV waste, but can provide considerable economic benefits if recycled wisely. The potential of secondary resources from PV waste may reduce the supply pressure on the natural materials to some extent, but they could not fully mitigate the material supply resks. We suggest that stakeholders in the solar energy industry should take urgent actions, including recycling technology innovations, effective collection systems and incentive measures, to address the growing challenge of waste PV panels in China.

Extraction of Polysaccharides from Root of Pseudostellaria heterophylla (Miq.) Pax. and the Effects of Ultrasound Treatment on Its Properties and Antioxidant and Immune Activities.

The hydrophilic polysaccharides (PS) were isolated and purified from the tuberous roots of Pseudostellaria heterophylla. The extraction process of PS from Pesudostellariae radix was optimized by single-factor experiments and orthogonal design. The extract was purified by DEAE cellulose column to obtain the pure polysaccharide PHP. Then PHP was treated with different intensities of sonication to study the effect of sonication on PHP's characteristics and its biological activity in vitro and in vivo. The results of this study revealed that ultrasound treatment did not significantly change the properties of PHP. Further, with the increase of ultrasound intensity, PHP enhanced the proliferation and phagocytosis of macrophage RAW264.7. Meanwhile, it could also significantly improve the body's antioxidant activity and immune function. The results of this study demonstrated that PHP has the potential as a food additive with enhanced antioxidant and immune functions, and its biological activities could be enhanced by sonication.

Mannose Receptor-Mediated Carbon Nanotubes as an Antigen Delivery System to Enhance Immune Response Both In Vitro and In Vivo.

Carbon nanotubes (CNTs) are carbon allotropes consisting of one, two, or more concentric rolled graphene layers. These can intrinsically regulate immunity by activating the innate immune system. Mannose receptors (MR), a subgroup of the C-type lectin superfamily, are abundantly expressed on macrophages and dendritic cells. These play a crucial role in identifying pathogens, presenting antigens, and maintaining internal environmental stability. Utilizing the specific recognition between mannose and antigen-presenting cells (APC) surface mannose receptors, the antigen-carrying capacity of mannose-modified CNTs can be improved. Accordingly, here, we synthesized the mannose-modified carbon nanotubes (M-MWCNT) and evaluated them as an antigen delivery system through a series of in vitro and in vivo experiments. In vitro, M-MWCNT carrying large amounts of OVA were rapidly phagocytized by macrophages and promoted macrophage proliferation to facilitate cytokines (IL-1ß, IL-6) secretion. In vivo, in mice, M-MWCNT induced the maturation of dendritic cells and increased the levels of antigen-specific antibodies (IgG, IgG1, IgG2a, IgG2b), and cytokines (IFN-γ, IL-6). Taken together, M-MWCNT could induce both humoral and cellular immune responses and thereby can be utilized as an efficient antigen-targeted delivery system.

Enhancement of immune responses using ovalbumin-conjugated Eucommia ulmoides leaf polysaccharides encapsulated in a cubic liquid-crystalline phase delivery system.

BACKGROUND: To improve the adjuvant activity of polysaccharides from Eucommia ulmoides leaves (PsEUL) in inducing an effective immune response against ovalbumin (OVA), PsEUL were conjugated to OVA using the N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) method. The synthesized PsEUL-OVA was encapsulated using phytantriol and F127 to produce PsEUL-OVA cubosomes (Cubs), a novel delivery system. The physicochemical properties and immune modulation effects of this novel delivery system were explored. RESULTS: In vitro, PsEUL-OVA/Cubs carrying large amounts of OVA were rapidly phagocytized by macrophages and upregulated macrophage proliferation, thereby stimulating cytokine production (interleukin (IL)-6 and IL-4). In vivo, PsEUL-OVA/Cubs increased the titer of OVA-specific antibodies (immunoglobulin (Ig)G, IgG2b, IgG2a and IgG1) and cytokine levels (IL-2, IL-6, IL-4 and interferon-γ). In addition, the cubosomes promoted the differentiation of CD8+ and CD4+ T cells in the spleen and the maturation of dendritic cells (DCs). These results indicated that PsEUL-OVA/Cubs stimulated both cellular and humoral immune responses by enhancing the phagocytic activity of DCs and macrophages and increasing the antigen presentation efficiency. CONCLUSION: Collectively, the findings demonstrate that PsEUL-antigen/Cubs can be a useful delivery vehicle with immune response-promoting effects. Therefore, this study lays the foundation for the development of novel adjuvant-antigen delivery systems with potential applications in vaccine design. © 2022 Society of Chemical Industry.

Study on Extraction Process of Root of Henry Wood Betony Polysaccharides and Their Antitumor Activity against S180.

We optimized the hot water extraction of polysaccharides from the root of Henry wood betony (RHWPs) using a uniform test and explored their anti-tumor activities in vitro and in vivo. The optimal extraction conditions were as follows: 40 min extraction time, liquid/solid ratio 30 mL/g, 100 min soaking time, two extraction cycles, 100% ethanol concentration, and extraction temperature of 80 °C. The molecular weight distribution of RHWPs with MWs was 228,600 g/mol and 5001 g/mol. The IR spectrum further indicated that RHWPs are acidic polysaccharides containing pyranose and furan rings. The main monosaccharides found in RHWPs were mannose, ribose, l-rhamnose monohydrate, glucuronic acid, galacturonic acid, glucose, galactose, xylose, arabinose, and fucose. RHWPs inhibited the proliferation of S180 tumor cells and induced apoptosis in vitro. Oral administration of RHWPs to tumor-bearing mice significantly inhibited the growth of the S180 xenografts, accelerated apoptosis in tumor cells, and expanded the necrotic regions. Furthermore, RHWPs also markedly increased the levels of TNF-α, IFN-γ, and IL-2 in the sera of tumor-bearing mice, and activated immune cells such as lymphocytes, NK cells, and macrophages, thereby inducing tumor cell apoptosis. Taken together, RHWPs are a promising anti-tumor agent that ought to be explored further.

Spatial-temporal evolutions of groundwater environment in prairie opencast coal mine area: a case study of Yimin Coal Mine, China.

The interactions between groundwater and its environment was investigated in prairie mining area in this study, through the groundwater system evolutions in mining area before and after the mining actions (from 1973 to 2016) of Yimin coal mine. The results showed that (1) the mining activities of the open-pit coal changed the original reduction environment into the oxidizing environment in the mining area. The pyrite and sulfur-bearing coal in the stratum oxidized, produced acid and triggered a series of subsequent reactions, resulting in the decrease in the pH value of the groundwater in the mining area. The concentration of SO42-, Fe2+, Fe3+, Ca2+ and Mg2+ and the total hardness increased. The regional hydrochemical type evolved from HCO3-Na·Ca·Mg type before mining to the type of HCO3·SO4-Na·Ca·Mg after mining. (2) Coal mining strongly draining underground water accelerated the regional groundwater circulation, and then made the groundwater desalination. The concentrations of TDS, COD and Na++K+ in the mining area all showed a decreasing trend. (3) The coal mining activities made the calcite and dolomite in saturated state under the natural condition of underground water to be unsaturated again. The hydro-geochemical action evolves from double control (water-rock interaction and evaporation-concentration) to water-rock interaction control.

Immunomodulatory Effects of Phosphorylated Radix Cyathulae officinalis Polysaccharides in Immunosuppressed Mice.

This research aimed to investigate the immunomodulatory effects of phosphorylated Radix Cyathulae officinalis Kuan polysaccharides (pRCPS) in immunosuppressed mice, improving their cellular and humoral immune function. Our results showed that pRCPS increased serum immunoglobulin (IgG, IgA, IgM) concentrations significantly, enhanced splenocyte proliferation, and the thymus and spleen indices. pRCPS also promoted phagocytosis in peritoneal macrophages and enhanced cytokine (IFN-γ, IL-2, -4, -5, -6, and -10) serum levels. Importantly, pRCPS increased the proportions of selected T cell subpopulations (CD3+, CD4+, and the CD4+ to CD8+ ratio). Our results revealed that phosphorylation of the polysaccharides promoted their immune-enhancing effects. Thus, pRCPS can enhance cellular and humoral immunity and could be used as an immune-enhancing agent to overcome cyclophosphamide (CY)-induced immunosuppression.

Phosphorylated Radix Cyathulae officinalis Polysaccharides Act as Adjuvant via Promoting Dendritic Cell Maturation.

The aim of this study was to investigate whether phosphorylated Radix Cyathulae officinalis Kuan polysaccharides (pRCPS) used as adjuvant with foot-and-mouth disease vaccine (FMDV) can stimulate specific humoral and cellular immune responses in ICR mice. The results demonstrated that pRCPS significantly up-regulated FMDV-specific IgG, IgG1, IgG2b and IgG2a antibody levels and splenocyte proliferation. pRCPS also promoted the killing activities of cytotoxic T lymphocytes (CTL) and natural killer cells (NK). In addition, pRCPS enhanced the expression levels of IL-2, IL-4, and IFN-γ in CD4⁺ T cells and the level of IFN-γ in CD8⁺ T cells. Importantly, pRCPS enhanced the expression of MHCII, CD40⁺, CD86⁺, and CD80⁺ in dendritic cells (DCs). This study indicated that phosphorylation modification could increase immune-enhancing activities of RCPS, and pRCPS could promote humoral and cellular immune responses through facilitating DC maturation.

[The Development of the Supermicroinvasive Magnetic Anchoring Laparoscopic System].

A magnetic anchoring supermicroinvasive laparoscopic system, including in vitro magnetic navigation handle and in vivo magnetic anchor laparoscopy is introduced. The magnetic anchor laparoscopic comprises an outer cannula, two data lines, a camera, a high color temperature LED light and two inner magnets. It is tiny enough to enter the abdominal cavity through conventional laparoscopic trocar and achieve orientation, navigation as wel as adjustment thefi eld of view within the abdominal cavity by attracting with the in vitro magnetic handle, thus it does not take up space of the laparoscopic trocar in working state. The system which can not only apply in single-port laparoscopic surgery based on a single traditional laparoscopic trocar but also apply in traditional laparoscopic surgery with less trocar, wil enhance the extent of minimaly invasive surgery and reduce the operation diffi culty at the same time. The clinical application of the system wil optimize the minimaly invasive techniques and benefi t the patients.

Sulfated radix Cyathulae officinalis polysaccharides act as adjuvant via promoting the dendritic cell maturation and suppressing Treg frequency.

This study was conducted to evaluate the adjuvant potential of sulfated Radix Cyathulae officinalis Kuan polysaccharides (sRCPS) and their effects on specific cellular and humoral immune responses to hepatitis B subunit vaccine in mice. Our data demonstrated that sRCPS significantly promoted the rHBsAg-specific IgG, IgG1, IgG2a, and IgG2b antibody titers, the activities of natural killer cells (NK) and cytotoxic T lymphocytes (CTL), T cells proliferation, and phagocytic capacity of peritoneal macrophages. Furthermore, sRCPS increased the levels of IL-4, IL-2, and IFN-γ in CD4(+)T cells and the level of IFN-γ in CD8(+)T cells. In addition, sRCPS enhanced the expression of CD40(+), CD80(+), CD86(+), MHC I and MHC II in dendritic cells (DCs) and upregulated the mRNA levels of MHC I, MHC II. sRCPS downregulated the frequency of CD4(+)CD25(+)Foxp3(+) Treg cells. sRCPS increased both cellular and humoral immune responses by upregulating DC maturation, and suppressing the frequency of Treg cells.

Mucosal and systemic immunity in mice after intranasal immunization with recombinant Lactococcus lactis expressing ORF6 of PRRSV.

The purpose of the study was to construct mucosal vaccine of a recombinant Lactococcus lactis expressing PRRSV ORF6 gene and evaluate mucosal and systemic immune response against PRRSV in mice after intranasal immunization. The result show that the vaccine can stimulate mice to produce specific IgG in serum and remarkable special s-IgA in lung lavage fluid, at the same time, the contents of cytokines IL-2 and IFN-γ of the experimental group were significant higher than those of the control group (P < 0.01), however, the contents of cytokines IL-4 was not different to the all groups. In summary, the constructed mucosal vaccine can significantly induce mucosal immune, humoral immunity and cellular immunity involved Th1 type cytokines, which will lay a theoretical foundation on immune mechanism and new efficient vaccines for PRRSV.

Self-assembly of nano/micro-structured Fe3O4 microspheres among 3D rGO/CNTs hierarchical networks with superior lithium storage performances.

Nano/micro-structured Fe3O4 microspheres among three-dimensional (3D) reduced graphene oxide (rGO)/carbon nanotubes (CNTs) hierarchical networks (the ternary composite is denoted as rGCFs) have been synthesized using a facile, self-assembled and one-pot hydrothermal approach. The rGCFs composite exhibits superior lithium storage performances: initial discharge and charge capacities of 1452 and 1036 mAh g(-1), respectively, remarkable rate capability at current densities from 100 mA g(-1) to 10 A g(-1) and outstanding cycling performance up to 200 cycles. The highly enhanced electrochemical performances of rGCFs depend heavily on the robust 3D rGO/CNTs hierarchical networks, the stable nano/microstructures of active Fe3O4 microspheres and the positive synergistic effects of building components. The systematic structure characterizations and electrochemical investigations provide insightful understanding towards the relationship between structure/morphology and lithium storage performances, which may pave the way for the rational design of composite materials with desirable goals.

Study on Ce2Fe14B-based sintered magnets with Ce/RE> 80.

Up to now, the development of Ce/RE> 80% sintered permanent magnets still faces a challenge, owing to their seriously deteriorated microstructure. In this article, the Ce25.5∼31.5Nd0∼5Febal.B1.25M1.15 (wt.%) sintered magnets with Ce/RE > 80% were investigated, the roles of minor Nd substitution were explored. The typical island-like phase common existed in the grain-boundary (GB) regions of Ce2Fe14B-based SC alloys (which destroys the continuity of RE-rich GB phase), was confirmed as a tetragonal B-rich phase (fct-RE5Fe18B18), and probably generated by the peritectic reaction of "L + Ce2Fe14B → CeFe2 + B-rich" at 797 °C. It was found that: the deteriorated microstructures of high Ce sintered magnets were hardly improved (Nd element was not enriched in the main phase as it was expected), and the coercivity increments were far below expectations by directly adding 3-5% Nd in alloy designs. However, the GB phase distribution was more uniform and continuous, Nd-rich shells formed, and magnetic properties were remarkably promoted by blending 2% NdHx powders into the Ce27.5Nd3Febal.B1.25M1.15 (Ce27.5Nd3) magnet during JM milling, compared with the Ce25.5Nd5Febal.B1.25M1.15 (Ce25.5Nd5) magnet with similar composition. The good comprehensive magnetic properties of Hcj = 1.714 kOe, Br = 9.395 kG, and (BH)max = 11.16 MGOe have been reached in the Ce27.5Nd3+2% (NdHx) magnet (Ce accounted for 84.5 wt% of total rare earth). The present work deepens our understanding of metallurgical behavior, process/microstructure designing for Ce/RE> 80% sintered magnets, and shed a light on the large-scale utilization of Ce element in a permanent magnet.

Bibliometric and visualized analysis of hydrogels in organoids research.

Over the past decades, there has been ongoing effort to develop complex biomimetic tissue engineering strategies for in vitro cultivation and maintenance of organoids. The defined hydrogels can create organoid models for various organs by changing their properties and various active molecules. An increasing number of researches has been done on the application of hydrogels in organoids, and a large number of articles have been published on the topic. Although there have been existing reviews describing the application of hydrogels in the field of organoids, there is still a lack of comprehensive studies summarizing and analyzing the overall research trends in this field. The citation can be used as an indicator of the scientific influence of an article in its field. This study aims to evaluate the application of hydrogels in organoids through bibliometric analysis, and to predict the hotspots and developing trends in this field.

Enhancement of the immune responses to foot-and-mouth disease vaccination in mice by oral administration of a novel polysaccharide from the roots of Radix Cyathulae officinalis Kuan (RC).

Foot-and-mouth disease (FMD) is a kind of the important animal infectious disease caused by the foot-and-mouth disease virus (FMDV). Thus, the aim of this study was to determine the effects of the polysaccharide from the Radix Cyathulae officinalis Kuan (RCPS) for its adjuvant potential on the FMDV-specific cellular and humoral immune responses in mice. In this study, our findings shows that oral administration of RCPS significantly enhanced the phagocytic capacity of peritoneal macrophage, splenocyte proliferation, the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL) and IgG, IgG1, IgG2a, and IgG2b antibody titers. Furthermore, RCPS promoted the level of IL-2, IFN-γ and IL-4 in CD4(+)T cells and level of IFN-γ in CD8(+)T cells. In addition, RCPS enhanced the expression of CD40(+), CD80(+) and CD86(+) on DCs. Importantly, RCPS could up-regulated the mRNA level of MHC I, MHC II, TLR-2, TLR-4. Interestingly, RCPS down-regulated the frequency of CD4(+)CD25(+)Foxp3(+)Treg cells. Taken together, these results demonstrate that RCPS can enhance both cellular and humoral immune responses via up-regulating DCs maturation through TLR2, TLR4 signaling pathway, and suppressing Treg frequency.

CO2 laser combined with low-temperature plasma radiofrequency ablation promotes recovery of swallowing function in elderly patients with early glottic carcinoma.

OBJECTIVE: This study was designed to determine the effect of CO2 laser combined with low-temperature plasma radiofrequency ablation (LPRA) on swallowing function and prognosis in elderly patients with early glottic laryngeal cancer (GLC). METHODS: The clinical data of 115 elderly patients with early GLC treated in General Hospital of Daqing Oil Field from May 2013 to September 2015 were retrospectively analyzed. These patients were assigned to a research group or control group according to different therapeutic regimen. Totally 56 cases treated with CO2 laser resection were assigned to the control group, and 59 cases treated with CO2 laser combined with LPRA were assigned to the research group. The hospital stay, postoperative pain, mucosal recovery score, postoperative complications, swallowing function, vocal function, and 5-year recurrence rate were compared between the two groups. Independent risk factors for 5-year recurrence in patients were analyzed by multivariate logistic regression. RESULTS: The research group was significantly superior to the control group in terms of hospital stay, postoperative pain, and mucosal recovery score (P<0.05), and the postoperative complication rate was not significantly different between the two groups (P>0.05). After treatment, the research group showed better swallowing function and vocal function than the control group, and the 5-year recurrence rate of the two groups was similar (P=0.288). Multivariate logistic regression analysis identified higher age, lower differentiation, and presence of a cumulative anterior commissure as independent risk factors for recurrence. CONCLUSION: CO2 laser combined with LPRA can provide relatively high clinical efficacy for early GLC in the elderly, after which patients' swallowing function and vocal function recover quickly, but the long-term benefit of adding LPRA is not evident.

How to Enhance Citizens' Sense of Gain in Smart Cities? A SWOT-AHP-TOWS Approach.

The previous technology-centric development of smart cities mainly focuses on the numbers, diversities, and types of applied intelligent technologies, while the citizen-centric smart city has become an important paradigm for improving the sustainability of cities around the world. The citizens' sense of gain (CSG), which considers both material acquisition and spiritual feelings of smart city services, is thus proposed and regarded as one of the core orientations in the smart cities' transformation development process from the centric of advanced technology applied to the centric of citizen subjective perception. To shift smart cities from being technology-centric to citizen-centric, it is critical to identify the factors influencing CSG and develop appropriate strategies to enhance CSG in smart cities. Hence, this work identifies 17 key CSG influencing factors based on the dimensions dissected from the definition of CSG and it further formulates 15 strategies for enhancing CSG by adopting the SWOT-AHP-TOWS method based on data collected from Nanjing citizens. The results indicate that the most important criteria for enhancing CSG in smart cities are the external opportunities, which are originated from citizens' attitudes and behaviors, and the top-ranked strategy is "dividing smart infrastructure into different categories according to the hierarchy needs of citizens and promoting the synergy development of smart infrastructure within and among different categories". Finally, four implications are proposed, including (i) strengthening publicity and encouraging citizen participation, (ii) clarifying the responsibilities of local governments, (iii) prioritizing citizens' needs, and (iv) promoting age-friendly, vulnerable-friendly, and environmental-friendly development.

Design and Control for WLR-3P: A Hydraulic Wheel-Legged Robot.

The robot used for disaster rescue or field exploration requires the ability of fast moving on flat road and adaptability on complex terrain. The hybrid wheel-legged robot (WLR-3P, prototype of the third-generation hydraulic wheel-legged robot) has the characteristics of fast and efficient mobility on flat surfaces and high environmental adaptability on rough terrains. In this paper, 3 design requirements are proposed to improve the mobility and environmental adaptability of the robot. To meet these 3 requirements, 2 design principles for each requirement are put forward. First, for light weight and low inertia with high stiffness, 3-dimensional printing technology and lightweight material are adopted. Second, the integrated hydraulically driven unit is used for high power density and fast response actuation. Third, the micro-hydraulic power unit achieves power autonomy, adopting the hoseless design to strengthen the reliability of the hydraulic system. What is more, the control system including hierarchical distributed electrical system and control strategy is presented. The mobility and adaptability of WLR-3P are demonstrated with a series of experiments. Finally, the robot can achieve a speed of 13.6 km/h and a jumping height of 0.2 m.

Impact of anthocyanins derived from Dioscorea alata L. on growth performance, carcass characteristics, antioxidant capacity, and immune function of Hainan black goats.

Dioscorea alata L. anthocyanins (DAC) are natural compounds found in plants and have shown potential health benefits. The objective of this investigation was to assess the impact of anthocyanins sourced from Dioscorea alata L. on the growth, carcass traits, antioxidant potential, and immune response of Hainan black goats. In this study, 30 three-month-old Hainan black goats (with a weight of 11.30 ± 0.82 kg) were selected and randomly divided into two groups, with 15 goats in each group. During the 60-day experiment, the control group (CON) and the treatment group (DAC) were, respectively, supplemented with 0 and 40 mg/kg BW of DAC in the basal diet. The results showed that DAC had no significant impact on the growth performance and body characteristics of Hainan black goats (p > 0.05). However, in terms of meat quality, the addition of DAC significantly increased the pH value and cooking yield 24 h post-slaughter (p < 0.05), while reducing the shear force of the meat (p < 0.05). Compared to the control group, adding DAC to the feed resulted in a significant increase in the total antioxidant capacity (T-AOC) and superoxide dismutase (T-SOD) concentrations in plasma after 30 days of feeding (p < 0.05). After 60 days of feeding, the concentrations of T-AOC, T-SOD, glutathione peroxidase (GSH-Px), and catalase (CAT) in the plasma of the DAC group was higher than that of the control group (p < 0.05), while the concentration of malondialdehyde (MDA) was lower than that of the control group (p < 0.05). In addition, supplementing DAC significantly increased the content of interleukin-10 (IL-10) and immunoglobulin M (IgM) in the plasma of Hainan black goats after 30 days of feeding (p < 0.05), while reducing the content of interleukin-6 (IL-6) (p < 0.05). After 60 days of feeding, the immunoglobulin G (IgG) and IL-10 content in the plasma of the DAC group was significantly increased (p < 0.05), while the concentrations of IL-1ß, IL-6, and tumor necrosis factor-α (TNF-α) were suppressed (p < 0.05). In summary, these results indicate that supplementing DAC can improve the meat quality, enhance the antioxidant capacity, and immune function of Hainan black goats.

Pre-Protection and Mechanism of Crude Extracts from Dioscorea alata L. on H2O2-Induced IPEC-J2 Cells Oxidative Damage.

The purple tubers of Dioscorea alata L. have been found to contain a variety of bioactive chemical components, including anthocyanins, which make it significant to investigate the pre-protective effects of Dioscorea alata L. and its crude extracts on cells prior to oxidative stress. To establish a suitable oxidative damage model, an injured model of IPEC-J2 cells was created using H2O2 as the oxidant. Specifically, when the concentration of H2O2 was 120 µmol/L and the injured time was 8 h, the survival rate of cells decreased to approximately 70%, and the cells exhibited a noticeable oxidative stress reaction. Moreover, the crude extracts of Dioscorea alata L. demonstrated beneficial pre-protective effects on IPEC-J2 cells by increasing the total antioxidant capacity (T-AOC) and catalase (CAT) activities, augmenting the expression of total superoxide dismutase (T-SOD) and its genes, reducing the content of malondialdehyde (MDA) and the activity of glutathione peroxidase (GSH-PX) and its expression of genes, and promoting the expression of glucose transporter SGLT1 gene while reducing that of GULT2 gene, thereby facilitating the entry of anthocyanins into cells. In addition, the 50 µg/mL crude extracts effectively inhibited the phosphorylation of IκB and the p65 protein, thus reducing cellular oxidative stress. Given these findings, Dioscorea alata L. can be considered a natural antioxidant for practical breeding and production purposes, with an optimal concentration of crude extracts in this experiment being 50 µg/mL.