RESUMO
YTHDC1 activates the DNA repair kinase ATR to suppress bleomycin-induced lung fibrosis.
Assuntos
Fibrose Pulmonar , Humanos , Reparo do DNARESUMO
Targeting a driver of TBK1 kinase activity may slow the growth of kidney tumors.
Assuntos
Carcinoma de Células Renais , Neoplasias Renais , Humanos , Proteínas Serina-Treonina Quinases/genética , Proteínas Serina-Treonina Quinases/metabolismo , Fosforilação , Neoplasias Renais/genéticaRESUMO
Opioids trigger myelin insulation of reward circuit axons in a feedforward loop of addiction.
Assuntos
Analgésicos Opioides , Humanos , Analgésicos Opioides/farmacologia , Animais , Axônios/metabolismo , Axônios/fisiologia , Bainha de Mielina/metabolismo , Recompensa , Transtornos Relacionados ao Uso de OpioidesRESUMO
Blocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses.
Assuntos
Doença de Alzheimer , Microglia , Humanos , Neurônios , Transdução de Sinais , SinapsesRESUMO
Astrocyte-secreted neurocan guides the formation of inhibitory circuits in the brain.
Assuntos
Sinapses , Sinapses/fisiologia , Sinapses/metabolismo , Humanos , Animais , Neuroglia/metabolismo , Neuroglia/fisiologia , Neuroglia/citologia , Astrócitos/metabolismo , Astrócitos/citologia , Astrócitos/fisiologia , Neurogênese/fisiologia , Encéfalo/fisiologia , Encéfalo/metabolismoRESUMO
Glia take up and detoxify neurotoxic lipids on a wake-sleep cycle, in turn promoting healthy sleep.
Assuntos
Neuroglia , Sono , Animais , Humanos , Neuroglia/metabolismo , Neuroglia/fisiologia , Sono/fisiologia , Vigília/fisiologiaRESUMO
Highlights from the Science family of journals.
RESUMO
Highlights from the Science family of journals.
RESUMO
Highlights from the Science family of journals.
RESUMO
Highlights from the Science family of journals.
RESUMO
Highlights from the Science family of journals.
RESUMO
Highlights from the Science family of journals.
RESUMO
Highlights from the Science family of journals.
RESUMO
Highlights from the Science family of journals.
RESUMO
Several studies show that there is still much to learn about cell death mechanisms.
Assuntos
Aprendizagem , Piroptose , Morte CelularRESUMO
Co-targeting glial cells may block the paradoxical increase in pain caused by repeated opioid use.
Assuntos
Analgésicos Opioides , Neuroglia , Humanos , Analgésicos Opioides/efeitos adversos , Dor/induzido quimicamenteRESUMO
EZH2 inhibitors may slow the progression of an aggressive form of adrenocortical cancer.
Assuntos
Neoplasias do Córtex Suprarrenal , Proteína Potenciadora do Homólogo 2 de Zeste , Humanos , Proteína Potenciadora do Homólogo 2 de Zeste/genética , Proteína Potenciadora do Homólogo 2 de Zeste/metabolismo , Neoplasias do Córtex Suprarrenal/genética , Inibidores Enzimáticos/farmacologia , Epigênese GenéticaRESUMO
A five-signal cue drives the switch to glia production in the developing fetal brain.
RESUMO
The loss of a secreted factor from astrocytes may underlie neuronal pathology in Fragile X syndrome.
Assuntos
Astrócitos , Síndrome do Cromossomo X Frágil , Humanos , Transporte Biológico , Síndrome do Cromossomo X Frágil/genéticaRESUMO
A high-protein diet may promote deep sleep by gut secretion of a dopamine neuron-stimulating peptide.