Detalhe da pesquisa
1.
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2.
Int J Mol Sci
; 24(3)2023 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36768458
2.
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells.
Molecules
; 27(9)2022 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35566369
3.
Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases.
Pharmacol Res
; 170: 105607, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34089867
4.
The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders.
Int J Mol Sci
; 22(22)2021 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34830256
5.
A Proteomic Approach Identified TFEB as a Key Player in the Protective Action of Novel CB2R Bitopic Ligand FD22a against the Deleterious Effects Induced by ß-Amyloid in Glial Cells.
Cells
; 13(10)2024 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38786097
6.
The Interplay between Cannabinoid Receptors and Microglia in the Pathophysiology of Alzheimer's Disease.
J Clin Med
; 12(23)2023 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38068253
7.
Dual Cannabinoid and Orexin Regulation of Anhedonic Behaviour Caused by Prolonged Restraint Stress.
Brain Sci
; 13(2)2023 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36831860
8.
CB1 receptor binding sites for NAM and PAM: A first approach for studying, new nbutyldiphenylcarboxamides as allosteric modulators.
Eur J Pharm Sci
; 169: 106088, 2022 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34863873
9.
Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R).
Front Chem
; 10: 984069, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36238097
10.
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.
J Med Chem
; 65(14): 9918-9938, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35849804
11.
Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor.
Eur J Med Chem
; 211: 113116, 2021 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33360803
12.
Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.
Eur J Med Chem
; 209: 112857, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33045662
13.
Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist.
Life (Basel)
; 10(12)2020 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33302569