Detalhe da pesquisa
1.
Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.
Bioorg Med Chem Lett
; 23(17): 4953-9, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23867164
2.
An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines.
Cancer Res
; 64(11): 3761-6, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15172981
3.
Small interfering RNA and gene expression analysis using a multiplex branched DNA assay without RNA purification.
J Biomol Screen
; 10(6): 549-56, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16103413
4.
Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis.
Mol Endocrinol
; 16(6): 1309-21, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12040017
5.
Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1.
J Med Chem
; 58(12): 5053-74, 2015 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25988399
6.
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.
Sci Transl Med
; 7(273): 273ra15, 2015 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25653221
7.
Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.
J Med Chem
; 57(3): 921-36, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24354345
8.
Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900.
Mol Cancer Ther
; 12(10): 1968-80, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23873850
9.
Potent and highly selective benzimidazole inhibitors of PI3-kinase delta.
J Med Chem
; 55(17): 7686-95, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22877085
10.
Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.
J Med Chem
; 55(22): 9416-33, 2012 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22985112
11.
A multiplex branched DNA assay for parallel quantitative gene expression profiling.
Anal Biochem
; 352(1): 50-60, 2006 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16545767
12.
Astrocytes from Na(+)-K(+)-Cl(-) cotransporter-null mice exhibit absence of swelling and decrease in EAA release.
Am J Physiol Cell Physiol
; 282(5): C1147-60, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11940530
13.
An alternate pathway of cAMP-stimulated Cl secretion across the NKCC1-null murine duodenum.
Gastroenterology
; 123(2): 531-41, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12145806
14.
Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter.
Am J Physiol Heart Circ Physiol
; 283(5): H1846-55, 2002 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12384462
15.
The unique ultrastructure of secretory membranes in gastric parietal cells depends upon the presence of H+, K+ -ATPase.
Cell Tissue Res
; 309(3): 369-80, 2002 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12195293