Detalhe da pesquisa
1.
Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.
Bioorg Med Chem Lett
; 25(6): 1338-42, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25677667
2.
Binding kinetics redefine the antagonist pharmacology of the corticotropin-releasing factor type 1 receptor.
J Pharmacol Exp Ther
; 341(2): 518-31, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22357972
3.
The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF1 receptor antagonist program.
Drug Discov Today
; 25(1): 7-14, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31557449
4.
Allosteric ligands for the corticotropin releasing factor type 1 receptor modulate conformational states involved in receptor activation.
Mol Pharmacol
; 73(5): 1371-80, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18239030
5.
Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
Bioorg Med Chem Lett
; 18(14): 4224-7, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18550369
6.
Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(17): 4817-22, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18682322
7.
Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(3): 1124-30, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18082401
8.
Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.
Bioorg Med Chem Lett
; 18(4): 1346-9, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18207394
9.
Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(6): 1931-8, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18294847
10.
Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.
Bioorg Med Chem Lett
; 18(23): 6151-5, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18954981
11.
Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.
Bioorg Med Chem Lett
; 18(13): 3682-6, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18539031
12.
Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.
Bioorg Med Chem Lett
; 18(11): 3328-32, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18445525
13.
Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors.
Bioorg Med Chem Lett
; 18(11): 3230-5, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18468895
14.
Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint.
Bioorg Med Chem Lett
; 18(16): 4495-8, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18667309
15.
Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.
Bioorg Med Chem Lett
; 18(16): 4491-4, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18672364
16.
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 18(1): 129-36, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032040
17.
Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.
Bioorg Med Chem
; 16(10): 5606-18, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18417348
18.
Studies on the structure-activity relationship of the basic amine of phenylpiperazines as melanocortin-4 receptor antagonists.
Med Chem
; 4(1): 67-74, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18220971
19.
Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.
J Med Chem
; 50(25): 6356-66, 2007 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994683
20.
Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia.
J Med Chem
; 50(22): 5249-52, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918824