Detalhe da pesquisa
1.
Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers.
J Infect Dis
; 229(4): 1077-1087, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37602681
2.
TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism.
Gut
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38697771
3.
Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure.
Gut
; 72(5): 972-983, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36707234
4.
Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro.
Gut
; 72(11): 2123-2137, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36717219
5.
Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression.
J Hepatol
; 78(3): 513-523, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38133554
6.
Hepatitis D virus interferes with hepatitis B virus RNA production via interferon-dependent and -independent mechanisms.
J Hepatol
; 78(5): 958-970, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36702177
7.
Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection.
Antimicrob Agents Chemother
; 67(1): e0134822, 2023 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36519892
8.
Toll-like receptor 7 agonist, GS-986, is an immune-stimulant inducing follicular helper T cells and expanding HBs antigen-specific B cells in vitro.
Liver Int
; 43(6): 1213-1224, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37029645
9.
Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo.
Gut
; 71(2): 372-381, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33509930
10.
Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Hepatology
; 73(1): 53-67, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32246499
11.
Therapeutic Potential of TLR8 Agonist GS-9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators.
Hepatology
; 74(1): 55-71, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33368377
12.
Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor.
Nature
; 531(7594): 386-9, 2016 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26983541
13.
Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes.
J Virol
; 93(16)2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167911
14.
Hepatitis B Virus X Protein Function Requires Zinc Binding.
J Virol
; 93(16)2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167910
15.
Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells.
J Hepatol
; 68(5): 912-921, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29247724
16.
Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism.
J Hepatol
; 68(5): 922-931, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29247725
17.
Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.
PLoS Pathog
; 11(9): e1005103, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26352406
18.
Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B.
J Hepatol
; 62(6): 1237-45, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25559326
19.
Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration.
J Hepatol
; 60(3): 500-7, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24398036
20.
Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B.
Hepatology
; 57(1): 13-22, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22806943