Detalhe da pesquisa
1.
Comparison of activity, structure, and dynamics of SF-1 and LRH-1 complexed with small molecule modulators.
J Biol Chem
; 299(8): 104921, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37328104
2.
Using Data Science for Mechanistic Insights and Selectivity Predictions in a Non-Natural Biocatalytic Reaction.
J Am Chem Soc
; 145(32): 17656-17664, 2023 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37530568
3.
Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A.
J Am Chem Soc
; 144(42): 19326-19336, 2022 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36223664
4.
Hydroarylation of Arenes via Reductive Radical-Polar Crossover.
J Am Chem Soc
; 142(20): 9163-9168, 2020 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32379445
5.
Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.
J Biol Chem
; 291(49): 25281-25291, 2016 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27694446
6.
A phospholipid mimetic targeting LRH-1 ameliorates colitis.
Cell Chem Biol
; 29(7): 1174-1186.e7, 2022 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35316658
7.
Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket.
J Med Chem
; 65(9): 6888-6902, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35503419
8.
Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors.
ACS Med Chem Lett
; 11(3): 365-370, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184971
9.
Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.
J Med Chem
; 62(24): 11022-11034, 2019 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31419141
10.
Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1.
ACS Med Chem Lett
; 9(10): 1051-1056, 2018 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344916