Detalhe da pesquisa
1.
Altered energy metabolism in Fatal Familial Insomnia cerebral organoids is associated with astrogliosis and neuronal dysfunction.
PLoS Genet
; 19(1): e1010565, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36656833
2.
A PrP EGFR signaling axis controls neural stem cell senescence through modulating cellular energy pathways.
J Biol Chem
; 299(11): 105319, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37802314
3.
PrPSc Oligomerization Appears Dynamic, Quickly Engendering Inherent M1000 Acute Synaptotoxicity.
Biophys J
; 119(1): 128-141, 2020 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32562618
4.
Prion propagation and cellular dysfunction in prion disease: Disconnecting the dots.
PLoS Pathog
; 19(10): e1011714, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37883332
5.
Sporadic Creutzfeldt-Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice.
Acta Neuropathol Commun
; 11(1): 28, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36788566
6.
Temporary alteration of neuronal network communication is a protective response to redox imbalance that requires GPI-anchored prion protein.
Redox Biol
; 63: 102733, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37172395
7.
Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model.
Stem Cell Res Ther
; 14(1): 348, 2023 12 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38049877
8.
Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function.
Sci Rep
; 12(1): 15788, 2022 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36138047
9.
Stress and viral insults do not trigger E200K PrP conversion in human cerebral organoids.
PLoS One
; 17(10): e0277051, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36301953
10.
A 3D cell culture approach for studying neuroinflammation.
J Neurosci Methods
; 358: 109201, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932455
11.
Reduced SOD2 expression does not influence prion disease course or pathology in mice.
PLoS One
; 16(11): e0259597, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34735539
12.
Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt-Jakob disease.
Sci Rep
; 11(1): 5165, 2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33727594
13.
Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases.
Mol Brain
; 14(1): 156, 2021 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34635127
14.
Pathogenic Prion Protein Isoforms Are Not Present in Cerebral Organoids Generated from Asymptomatic Donors Carrying the E200K Mutation Associated with Familial Prion Disease.
Pathogens
; 9(6)2020 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32570796
15.
Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids.
Acta Neuropathol Commun
; 7(1): 90, 2019 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31196223
16.
Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer.
JCI Insight
; 52019 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30830863