RESUMO
The article considers several practical situations requiring estimation of economic effectiveness. The protocols of estimation, costs and effectiveness accounting requirements of practical public health are proposed. The necessity of development of correct epidemiological model is demonstrated to estimate profit of innovations of diagnostic stage. The estimation "costs-effectiveness" is made for troponins at diagnostic of cardiac infarction and prostate-specific antigen under screening of prostate cancer.
Assuntos
Análise Custo-Benefício , Infarto/economia , Ciência de Laboratório Médico/economia , Neoplasias da Próstata/economia , Algoritmos , Humanos , Infarto/diagnóstico , Masculino , Antígeno Prostático Específico/economia , Neoplasias da Próstata/diagnóstico , Troponina C/economiaRESUMO
The choice of technology of electrophoretic fractionating of blood serum proteins is determined, besides the analytical characteristics, by its economic component. The electrophoresis technologies developed by the R&D production facility "Astra" (Russia) and the firm "PZ Cormay S.A." (Poland) are compared from a viewpoint of applicability in routine laboratory, practice and diagnostics of multiple plasma cell myeloma in particular. It is established that under the comparable economic, "consumer" and analytic characteristics of technologies in the diagnostic process the application of the technology in agarose gel ("PZ Cormay S.A.") is more preferable.
Assuntos
Eletroforese em Gel de Ágar/métodos , Eletroforese em Acetato de Celulose/métodos , Proteínas Sanguíneas , Eletroforese em Gel de Ágar/economia , Eletroforese em Gel de Ágar/instrumentação , Eletroforese em Acetato de Celulose/economia , Eletroforese em Acetato de Celulose/instrumentação , Humanos , Mieloma Múltiplo/diagnósticoRESUMO
The efficacy of eremomycin, a new glycopeptide antibiotic, was studied on a model of antibiotic-associated colitis in golden hamsters. The colitis was induced by intraperitoneal or intragastric administration of lincomycin. In a dose of 100 mg/kg administered orally once a day for 5 days eremomycin protected the animals from the lincomycin-induced colitis: some animals survived, the others died in later periods. When the animals were infected with a pathogenetic strain of Clostridium difficile followed by exposure to lincomycin the use of eremomycin produced the similar effect.