RESUMO
The aim of this work was to evaluate in vitro the tromboresistence, hemolysis tendency, platelet adhesion, cytotoxicity, physicochemical properties, and stability of open-heart tubing coated with fractionated heparin-benzalkonium chloride and/or lipid dipalmitoyl L-alpha-phosphatidylcholine (DPPC). The tendency for clot formation and platelet adhesion was greater in noncoated and lipid-coated tubing than in heparin-coated tubing. There were no significant differences between the hemolytic potentials of coated and noncoated tubing. The coatings were stable during the time of the experiment. The coatings did not present cytotoxicity and physicochemical alterations.
Assuntos
Anticoagulantes , Procedimentos Cirúrgicos Cardíacos/instrumentação , Materiais Revestidos Biocompatíveis , Circulação Extracorpórea/instrumentação , Fibrinolíticos , Heparina , Lipídeos , 1,2-Dipalmitoilfosfatidilcolina , Animais , Anticoagulantes/farmacologia , Compostos de Benzalcônio , Sobrevivência Celular/efeitos dos fármacos , Fenômenos Químicos , Físico-Química , Materiais Revestidos Biocompatíveis/farmacologia , Estabilidade de Medicamentos , Estudos de Avaliação como Assunto , Fibrinolíticos/farmacologia , Fibroblastos/efeitos dos fármacos , Hemólise/efeitos dos fármacos , Heparina/farmacologia , Intubação/instrumentação , Lipídeos/farmacologia , Adesividade Plaquetária/efeitos dos fármacos , Cloreto de Polivinila , Conservantes Farmacêuticos , Coelhos , Propriedades de Superfície , Tensoativos , Trombose/prevenção & controleRESUMO
The term calcium phosphate cement was introduced by Gruninger et al. (1). This type of cement can be prepared by reacting a calcium phosphate salt with an aqueous solution, which causes it to set by the crossing of the precipitated crystals. These cements offer a series of advantages that allow their use as grafts and substitutes of damaged parts of the bone system. However, these cements have low mechanical strength compared to human bones. This work studied the influence of the use of polyamide fibers in the mechanical properties of a calcium phosphate cement based on alpha-tricalcium phosphate as well as the mechanisms involved in the increase of mechanical strength. The results demonstrate the feasibility of the use of polymeric fibers to increase mechanical strength and the need for coupling agents for the effective performance of the fibers as reinforcement in these materials.