Strong current response to slow modulation: A metabolic case-study.

We study the current response to periodic driving of a crucial biochemical reaction network, namely, substrate inhibition. We focus on the conversion rate of substrate into product under time-varying metabolic conditions, modeled by a periodic modulation of the product concentration. We find that the system exhibits a strong nonlinear response to small driving frequencies both for the mean time-averaged current and for the fluctuations. For the first, we obtain an analytic formula by coarse-graining the original model to a solvable one. The result is nonperturbative in the modulation amplitude and frequency. We then refine the picture by studying the stochastic dynamics of the full system using a large deviation approach that allows us to show the resonant effect at the level of the time-averaged variance and signal-to-noise ratio. Finally, we discuss how this nonequilibrium effect may play a role in metabolic and synthetic networks.

Relaxation-speed crossover in anharmonic potentials.

In a recent Letter [A. Lapolla and A. Godec, Phys. Rev. Lett. 125, 110602 (2020)PRLTAO0031-900710.1103/PhysRevLett.125.110602], thermal relaxation was observed to occur faster from cold to hot (heating) than from hot to cold (cooling). Here we show that overdamped diffusion in anharmonic potentials generically exhibits both faster heating and faster cooling, depending on the initial temperatures and on the potential's degree of anharmonicity. We draw a relaxation-speed phase diagram that localizes the different behaviors in parameter space. In addition to faster-heating and faster-cooling regions, we identify a crossover region in the phase diagram, where heating is initially slower but asymptotically faster than cooling. The structure of the phase diagram is robust against the inclusion of a confining, harmonic term in the potential as well as moderate changes of the measure used to define initially equidistant temperatures.