Detalhe da pesquisa
1.
De Novo and Bi-allelic Pathogenic Variants in NARS1 Cause Neurodevelopmental Delay Due to Toxic Gain-of-Function and Partial Loss-of-Function Effects.
Am J Hum Genet
; 107(2): 311-324, 2020 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738225
2.
Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.
J Biol Chem
; 294(14): 5365-5385, 2019 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30670594
3.
Characterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry.
Methods
; 113: 64-71, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27794454
4.
The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.
Biochemistry
; 56(28): 3619-3631, 2017 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28632987
5.
Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo.
Proc Natl Acad Sci U S A
; 111(51): E5508-17, 2014 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25489076
6.
Standardizing analysis of circulating microRNA: clinical and biological relevance.
J Cell Biochem
; 115(5): 805-11, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24357537
7.
Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer.
BMC Cancer
; 14: 620, 2014 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25163878
8.
Regulation of angiogenesis by aminoacyl-tRNA synthetases.
Int J Mol Sci
; 15(12): 23725-48, 2014 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25535072
9.
The catechol moiety of obafluorin is essential for antibacterial activity.
RSC Chem Biol
; 4(11): 926-941, 2023 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37920400
10.
Aminoacyl-Transfer RNA Synthetases: Connecting Nutrient Status to Angiogenesis Through the Unfolded Protein Response.
Arterioscler Thromb Vasc Biol
; 36(4): 582-3, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27010025
11.
Fidelity escape by the unnatural amino acid ß-hydroxynorvaline: an efficient substrate for Escherichia coli threonyl-tRNA synthetase with toxic effects on growth.
Biochemistry
; 50(6): 1101-9, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21222438
12.
Substrate specificity and catalysis by the editing active site of Alanyl-tRNA synthetase from Escherichia coli.
Biochemistry
; 50(9): 1474-82, 2011 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21241052
13.
Aminoacyl transfer rate dictates choice of editing pathway in threonyl-tRNA synthetase.
J Biol Chem
; 285(31): 23810-7, 2010 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20504770
14.
The α-amino group of the threonine substrate as the general base during tRNA aminoacylation: a new version of substrate-assisted catalysis predicted by hybrid DFT.
J Phys Chem A
; 115(45): 13050-60, 2011 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21942566
15.
RNA-assisted catalysis in a protein enzyme: The 2'-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase.
Proc Natl Acad Sci U S A
; 105(46): 17748-53, 2008 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18997014
16.
Neuropathy-associated histidyl-tRNA synthetase variants attenuate protein synthesis in vitro and disrupt axon outgrowth in developing zebrafish.
FEBS J
; 288(1): 142-159, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32543048
17.
Asymmetric amino acid activation by class II histidyl-tRNA synthetase from Escherichia coli.
J Biol Chem
; 284(31): 20753-62, 2009 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-19487703
18.
Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a ß-Lactone Antibiotic.
ACS Chem Biol
; 14(12): 2663-2671, 2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31675206
19.
DNA polymerases and aminoacyl-tRNA synthetases: shared mechanisms for ensuring the fidelity of gene expression.
Biochemistry
; 47(45): 11695-703, 2008 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18850722
20.
Correction: A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases.
PLoS One
; 13(1): e0190757, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29293641