Detalhe da pesquisa
1.
Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516.
Bioorg Med Chem Lett
; 28(3): 533-536, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29275935
2.
Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing.
Bioorg Med Chem Lett
; 27(23): 5230-5234, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29103972
3.
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.
Proc Natl Acad Sci U S A
; 106(12): 4635-40, 2009 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19261853
4.
Botulinum neurotoxin serotype A inhibitors: small-molecule mercaptoacetamide analogs.
Bioorg Med Chem
; 17(8): 3072-9, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19329331
5.
Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.
Toxicon
; 137: 36-47, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28698055
6.
Development and advanced validation of an optimized method for the quantitation of Aß42 in human cerebrospinal fluid.
AAPS J
; 14(3): 510-8, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22552903
7.
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.
J Biol Chem
; 283(24): 16895-905, 2008 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18343814
8.
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.
Biochemistry
; 46(24): 7107-18, 2007 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17530780