Pesquisa | Biblioteca Virtual em Saúde

1.

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.

Maude, Shannon L; Tasian, Sarah K; Vincent, Tiffaney; Hall, Junior W; Sheen, Cecilia; Roberts, Kathryn G; Seif, Alix E; Barrett, David M; Chen, I-Ming; Collins, J Racquel; Mullighan, Charles G; Hunger, Stephen P; Harvey, Richard C; Willman, Cheryl L; Fridman, Jordan S; Loh, Mignon L; Grupp, Stephan A; Teachey, David T.

Blood ; 120(17): 3510-8, 2012 Oct 25.

Artigo em Inglês | MEDLINE | ID: mdl-22955920

2.

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.

Zhou, Bin-Bing S; Peyton, Michael; He, Biao; Liu, Changnian; Girard, Luc; Caudler, Eian; Lo, Yvonne; Baribaud, Frederic; Mikami, Iwao; Reguart, Noemi; Yang, Gengjie; Li, Yanlong; Yao, Wenqing; Vaddi, Kris; Gazdar, Adi F; Friedman, Steven M; Jablons, David M; Newton, Robert C; Fridman, Jordan S; Minna, John D; Scherle, Peggy A.

Cancer Cell ; 10(1): 39-50, 2006 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-16843264

3.

Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis.

Verstovsek, Srdan; Kantarjian, Hagop; Mesa, Ruben A; Pardanani, Animesh D; Cortes-Franco, Jorge; Thomas, Deborah A; Estrov, Zeev; Fridman, Jordan S; Bradley, Edward C; Erickson-Viitanen, Susan; Vaddi, Kris; Levy, Richard; Tefferi, Ayalew.

N Engl J Med ; 363(12): 1117-27, 2010 Sep 16.

Artigo em Inglês | MEDLINE | ID: mdl-20843246

4.

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo.

Hemann, Michael T; Fridman, Jordan S; Zilfou, Jack T; Hernando, Eva; Paddison, Patrick J; Cordon-Cardo, Carlos; Hannon, Gregory J; Lowe, Scott W.

Nat Genet ; 33(3): 396-400, 2003 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-12567186

5.

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.

Quintás-Cardama, Alfonso; Vaddi, Kris; Liu, Phillip; Manshouri, Taghi; Li, Jun; Scherle, Peggy A; Caulder, Eian; Wen, Xiaoming; Li, Yanlong; Waeltz, Paul; Rupar, Mark; Burn, Timothy; Lo, Yvonne; Kelley, Jennifer; Covington, Maryanne; Shepard, Stacey; Rodgers, James D; Haley, Patrick; Kantarjian, Hagop; Fridman, Jordan S; Verstovsek, Srdan.

Blood ; 115(15): 3109-17, 2010 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-20130243

6.

Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis.

Koppikar, Priya; Abdel-Wahab, Omar; Hedvat, Cyrus; Marubayashi, Sachie; Patel, Jay; Goel, Aviva; Kucine, Nicole; Gardner, Jeffrey R; Combs, Andrew P; Vaddi, Kris; Haley, Patrick J; Burn, Timothy C; Rupar, Mark; Bromberg, Jacqueline F; Heaney, Mark L; de Stanchina, Elisa; Fridman, Jordan S; Levine, Ross L.

Blood ; 115(14): 2919-27, 2010 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-20154217

7.

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity.

Liu, Xiangdong; Shin, Niu; Koblish, Holly K; Yang, Gengjie; Wang, Qian; Wang, Kathy; Leffet, Lynn; Hansbury, Michael J; Thomas, Beth; Rupar, Mark; Waeltz, Paul; Bowman, Kevin J; Polam, Padmaja; Sparks, Richard B; Yue, Eddy W; Li, Yanlong; Wynn, Richard; Fridman, Jordan S; Burn, Timothy C; Combs, Andrew P; Newton, Robert C; Scherle, Peggy A.

Blood ; 115(17): 3520-30, 2010 Apr 29.

Artigo em Inglês | MEDLINE | ID: mdl-20197554

8.

Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050.

Fridman, Jordan S; Scherle, Peggy A; Collins, Robert; Burn, Timothy C; Li, Yanlong; Li, Jun; Covington, Maryanne B; Thomas, Beth; Collier, Paul; Favata, Margaret F; Wen, Xiaoming; Shi, Jack; McGee, Ryan; Haley, Patrick J; Shepard, Stacey; Rodgers, James D; Yeleswaram, Swamy; Hollis, Greg; Newton, Robert C; Metcalf, Brian; Friedman, Steven M; Vaddi, Kris.

J Immunol ; 184(9): 5298-307, 2010 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-20363976

9.

Dissecting p53 tumor suppressor functions in vivo.

Schmitt, Clemens A; Fridman, Jordan S; Yang, Meng; Baranov, Eugene; Hoffman, Robert M; Lowe, Scott W.

Cancer Cell ; 1(3): 289-98, 2002 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-12086865

10.

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.

Wendel, Hans-Guido; De Stanchina, Elisa; Fridman, Jordan S; Malina, Abba; Ray, Sagarika; Kogan, Scott; Cordon-Cardo, Carlos; Pelletier, Jerry; Lowe, Scott W.

Nature ; 428(6980): 332-7, 2004 Mar 18.

Artigo em Inglês | MEDLINE | ID: mdl-15029198

11.

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.

Burger, Renate; Le Gouill, Steven; Tai, Yu-Tzu; Shringarpure, Reshma; Tassone, Pierfrancesco; Neri, Paola; Podar, Klaus; Catley, Laurence; Hideshima, Teru; Chauhan, Dharminder; Caulder, Eian; Neilan, Claire L; Vaddi, Kris; Li, Jun; Gramatzki, Martin; Fridman, Jordan S; Anderson, Kenneth C.

Mol Cancer Ther ; 8(1): 26-35, 2009 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19139110

12.

Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.

Burns, David M; Li, Yun-Long; Shi, Eric; He, Chunhong; Xu, Meizhong; Zhuo, Jincong; Zhang, Colin; Qian, Ding-Quan; Li, Yanlong; Wynn, Richard; Covington, Maryanne B; Katiyar, Kamna; Marando, Cindy A; Fridman, Jordan S; Scherle, Peggy; Friedman, Steve; Metcalf, Brian; Yao, Wenqing.

Bioorg Med Chem Lett ; 19(13): 3525-30, 2009 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-19457660

13.

Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations.

Burns, David M; He, Chunhong; Li, Yanlong; Scherle, Peggy; Liu, Xiangdong; Marando, Cindy A; Covington, Mayanne B; Yang, Gengjie; Pan, Max; Turner, Sharon; Fridman, Jordan S; Hollis, Gregory; Vaddi, Kris; Yeleswaram, Swamy; Newton, Robert; Friedman, Steve; Metcalf, Brian; Yao, Wenqing.

Bioorg Med Chem Lett ; 18(2): 560-4, 2008 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-18068976

14.

Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.

Yao, Wenqing; Zhuo, Jincong; Burns, David M; Li, Yun-Long; Qian, Ding-Quan; Zhang, Colin; He, Chunhong; Xu, Meizhong; Shi, Eric; Li, Yanlong; Marando, Cindy A; Covington, Maryanne B; Yang, Gengjie; Liu, Xiangdong; Pan, Max; Fridman, Jordan S; Scherle, Peggy; Wasserman, Zelda R; Hollis, Gregory; Vaddi, Kris; Yeleswaram, Swamy; Newton, Robert; Friedman, Steve; Metcalf, Brian.

Bioorg Med Chem Lett ; 18(1): 159-63, 2008 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-18036818

15.

Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer.

Fridman, Jordan S; Caulder, Eian; Hansbury, Michael; Liu, Xiangdong; Yang, Genjie; Wang, Qian; Lo, Yvonne; Zhou, Bin-Bing; Pan, Maxwell; Thomas, Sufi M; Grandis, Jennifer R; Zhuo, Jincong; Yao, Wenqing; Newton, Robert C; Friedman, Steven M; Scherle, Peggy A; Vaddi, Kris.

Clin Cancer Res ; 13(6): 1892-902, 2007 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-17363546

16.

Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.

Yao, Wenqing; Zhuo, Jincong; Burns, David M; Xu, Meizhong; Zhang, Colin; Li, Yun-Long; Qian, Ding-Quan; He, Chunhong; Weng, Lingkai; Shi, Eric; Lin, Qiyan; Agrios, Costas; Burn, Timothy C; Caulder, Eian; Covington, Maryanne B; Fridman, Jordan S; Friedman, Steven; Katiyar, Kamna; Hollis, Gregory; Li, Yanlong; Liu, Changnian; Liu, Xiangdong; Marando, Cindy A; Newton, Robert; Pan, Max; Scherle, Peggy; Taylor, Nancy; Vaddi, Kris; Wasserman, Zelda R; Wynn, Richard; Yeleswaram, Swamy; Jalluri, Ravi; Bower, Michael; Zhou, Bing-Bing; Metcalf, Brian.

J Med Chem ; 50(4): 603-6, 2007 Feb 22.

Artigo em Inglês | MEDLINE | ID: mdl-17256836

17.

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.

Yue, Eddy W; Sparks, Richard; Polam, Padmaja; Modi, Dilip; Douty, Brent; Wayland, Brian; Glass, Brian; Takvorian, Amy; Glenn, Joseph; Zhu, Wenyu; Bower, Michael; Liu, Xiangdong; Leffet, Lynn; Wang, Qian; Bowman, Kevin J; Hansbury, Michael J; Wei, Min; Li, Yanlong; Wynn, Richard; Burn, Timothy C; Koblish, Holly K; Fridman, Jordan S; Emm, Tom; Scherle, Peggy A; Metcalf, Brian; Combs, Andrew P.

ACS Med Chem Lett ; 8(5): 486-491, 2017 May 11.

Artigo em Inglês | MEDLINE | ID: mdl-28523098

18.

Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab.

Liu, Xiangdong; Fridman, Jordan S; Wang, Qian; Caulder, Eian; Yang, Gengjie; Covington, Maryanne; Liu, Changnian; Marando, Cindy; Zhuo, Jincong; Li, Yanlong; Yao, Wenqing; Vaddi, Kris; Newton, Robert C; Scherle, Peggy A; Friedman, Steven M.

Cancer Biol Ther ; 5(6): 648-56, 2006 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-16627988

19.

Tumor promotion by Mdm2 splice variants unable to bind p53.

Fridman, Jordan S; Hernando, Eva; Hemann, Michael T; de Stanchina, Elisa; Cordon-Cardo, Carlos; Lowe, Scott W.

Cancer Res ; 63(18): 5703-6, 2003 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-14522887

20.

Control of apoptosis by p53.

Fridman, Jordan S; Lowe, Scott W.

Oncogene ; 22(56): 9030-40, 2003 Dec 08.

Artigo em Inglês | MEDLINE | ID: mdl-14663481

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