Detalhe da pesquisa
1.
Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5-13 (C10A).
Proteins
; 76(3): 536-47, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19274732
2.
Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Bioorg Med Chem Lett
; 19(15): 4050-4, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19553114
3.
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Bioorg Med Chem
; 16(14): 6965-75, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18541433
4.
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
J Med Chem
; 49(15): 4455-8, 2006 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16854050
5.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J Med Chem
; 49(12): 3520-35, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759095
6.
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
J Med Chem
; 49(12): 3563-80, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759099
7.
Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.
Protein Sci
; 14(12): 3039-47, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16322581
8.
Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
ACS Chem Biol
; 6(3): 234-44, 2011 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21090814
9.
Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.
J Med Chem
; 53(8): 3142-53, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20337371
10.
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
Bioorg Med Chem Lett
; 17(3): 668-72, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17107797
11.
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode.
Bioorg Med Chem Lett
; 16(7): 1811-5, 2006 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16442285
12.
Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.
Bioorg Med Chem Lett
; 16(7): 1807-10, 2006 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16446092
13.
Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.
Bioorg Med Chem Lett
; 16(10): 2590-4, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16527482
14.
Structure-based optimization of MurF inhibitors.
Chem Biol Drug Des
; 67(1): 58-65, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16492149
15.
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.
Biochemistry
; 45(24): 7474-82, 2006 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16768443