1.
Bioorg Med Chem Lett
; 13(7): 1337-40, 2003 Apr 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12657277
RESUMO
A series of newly synthesized phosphonate esters were evaluated for their effects on microsomal triglyceride transfer protein activity (MTP). The most potent compounds were evaluated for their ability to inhibit lipoprotein secretion in HepG2 cells and to affect VLDL secretion in rats. These inhibitors were also found to lower serum cholesterol levels in a hamster model upon oral dosing.