Detalhe da pesquisa
1.
Leveraging Advanced In Silico Techniques in Early Drug Discovery: A Study of Potent Small-Molecule YAP-TEAD PPI Disruptors.
J Chem Inf Model
; 63(8): 2520-2531, 2023 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37010474
2.
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Nature
; 543(7647): 733-737, 2017 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28329763
3.
Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence.
Bioorg Med Chem Lett
; 29(16): 2316-2319, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235263
4.
Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its Predominant Metabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy.
Biochemistry
; 57(38): 5576-5590, 2018 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30148617
5.
In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor.
Bioorg Med Chem Lett
; 28(20): 3404-3408, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217415
6.
Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.
Bioorg Med Chem Lett
; 26(8): 2065-7, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951750
7.
Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.
Bioorg Med Chem Lett
; 26(19): 4837-4841, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27542305
8.
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Bioorg Med Chem Lett
; 26(8): 2057-64, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951753
9.
Bioorthogonal Probes for the Study of MDM2-p53 Inhibitors in Cells and Development of High-Content Screening Assays for Drug Discovery.
Angew Chem Int Ed Engl
; 55(52): 16026-16030, 2016 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27874234
10.
Discovery of a novel tricyclic 4H-thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity.
Bioorg Med Chem Lett
; 25(17): 3582-4, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26164189
11.
Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.
Bioorg Med Chem Lett
; 25(17): 3621-5, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26141769
12.
Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 25(17): 3575-81, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26199119
13.
Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 25(17): 3569-74, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26206504
14.
Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction.
Bioorg Med Chem Lett
; 24(9): 2110-4, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24704029
15.
Dissecting the Interaction Fingerprints and Binding Affinity of BYL719 Analogs Targeting PI3Kα.
J Phys Chem B
; 128(8): 1819-1829, 2024 Feb 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38373112
16.
Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.
Nat Cancer
; 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38565920
17.
The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences.
Chembiochem
; 14(10): 1218-25, 2013 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23780915
18.
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.
Bioorg Med Chem Lett
; 23(13): 3741-8, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23726034
19.
Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.
ChemMedChem
; 18(11): e202300051, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36988034
20.
Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.
J Med Chem
; 66(13): 9095-9119, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37399505