Synthesis of imine bond containing insoluble polymeric ligand and its transition metal complexes, structural characterization and catalytic activity on esterification reaction.

In this study, synthesis of insoluble polymeric ligand (L) and its transition metal complexes [Cu(L)Cl2]·2H2O (1), [Co(L)Cl2(H2O)2] (2) and [Ni(L)Cl2(H2O)2] (3), having the azomethine groups, were synthesized by the condensation reactions of the diamines and dialdehydes. The structural properties were characterized by the analytical and spectroscopic methods using by elemental analysis, Fourier Transform Infrared, Thermo Gravimetric Analysis, Powder X-ray Diffraction, magnetic susceptibility and Inductively Coupled Plasma. The solubilities of the synthesized polymeric materials were also investigated and found as insoluble some organic and inorganic solvents. Additionally, their catalytic performance was carried out for the esterification reaction of acetic acid and butyl acetate. The highest conversion rate is 75.75% by using catalyst 1. The esterification of butanol gave butyl acetate with 100% selectivity.

2-[(3,4-Di-chloro-benzyl-idene)amino]-4-methyl-phenol.

In the title compound, C14H11Cl2NO, the dihedral angle between the benzene rings is 15.36 (8)°. A phenol-imine-type intra-molecular O-H⋯N hydrogen bond generates an S(5) ring motif. In the crystal, a pair of weak C-H⋯O hydrogen bonds form an R 2 (1)(7) ring motif involving glide-plane-related mol-ecules. The mol-ecules linked via these inter-actions form chains along [101].

Novel Copper Bearing Schiff Bases with Photodynamic Anti-Inflammatory and Anti-Microbial Activities.

Schiff bases and their copper complexes have been previously studied for their anti-inflammatory, anti-tumor as well as anti-microbial activities. Schiff bases can be derivatized to gain photoluminiscence capacity. This property of the schiff bases enables the transfer of the electrons upon absorption of the light at a specific wavelength. In this study, we exploited this attribute of novel copper bearing schiff bases and tested their photodynamic biological activities. These compounds exerted photodynamic anti-inflammatory activities on the in vitro activated mammalian macrophages. Compared with salicylic acid control groups, these novel schiff bases had stronger activity which became more prominent with photo-induction. Moreover, they also had anti-microbial activity on gram negative bacteria E.coli and gram positive bacteria S.aureus.This anti-microbial activity was stronger than that of Neomycin on both bacterial strains. Our results suggest their potential use as anti-inflammatory and anti-microbial agents both in the dark as well as after photo-induction.

Differential Immunomodulatory Activities of Schiff Base Complexes Depending on their Metal Conjugation.

Immunomodulatory compounds have become crucial with advances in immunotherapy. Using our own immune system cells, we can direct the immune cell function and develop desired response against a certain threat. Immunotherapy applications have been suggested against tumors, autoimmune disorders, and infectious diseases. Vaccination can be considered as one of the best known example of immunotherapy. Infectious agent's signature molecular structures are introduced to the immune cells together with the adjuvants that further activate the immune cells to mount a proper immune response and memory. Immunotherapy and vaccine formulations are in constant need of a library of immunomodulatory reagents that can be applied depending on the target. In order to expand the number of immunomodulatory reagents that can find medicinal applications, our group has been testing unique chemical structures on the immune system cells, especially macrophages. Schiff base complexes are known for their anti-inflammatory and antimicrobial activities. In this study, we used previously characterized Schiff base complexes with different metal conjugations. These molecules had differential immunostimulatory and immunomodulatory potentials on macrophages in vitro depending on the type of the conjugated metal. After light exposure, these complexes changed their characteristics and became powerful anti-inflammatory complexes. Due to their possible antimicrobial potentials, we also tested their activities against gram negative and gram positive bacteria. All of the complexes exerted antimicrobial activities which were not light responsive. Here, we present Schiff base complexes with differential immunostimulatory and immunomodulatory activities that can also efficiently eliminate gram positive and gram negative bacteria. Upon photo activation, they block the production of inflammatory TNFα cytokine. Therefore, together with the light, they can be used to treat bacterial infections associated with damaging inflammation. Graphical Abstract.

Monodentate Schiff base ligands: their structural characterization, photoluminescence, anticancer, electrochemical and sensor properties.

Two Schiff base compounds, N,N'-bis(2-methoxy phenylidene)-1,5-diamino naphthalene (L(1)) and N,N'-bis(3,4,5-trimethoxy phenylidene)-1,5-diamino naphthalene (L(2)) were synthesized and characterized by the analytical and spectroscopic methods. The electrochemical and photoluminescence properties of the Schiff bases were investigated in the different conditions. The compounds L(1) and L(2) show the reversible redox processes at some potentials. The sensor properties of the Schiff bases were examined and color changes were observed upon addition of the metal cations, such as Hg(II), Cu(II), Co(II) and Al(III). The Schiff base compounds show the bathochromic shift from 545 to 585 nm. The single crystals of the compounds (L(1)) and (L(2)) were obtained from the methanol solution and characterized structurally by the X-ray crystallography technique. The molecule L(2) is centrosymmetric whereas the L(1) has no crystallographically imposed molecular symmetry. However, the molecular structures for these compounds are quite similar, differing principally in the conformation about methoxy groups and the dihedral angle between the two aromatic rings and diamine naphthalene.