Detalhe da pesquisa
1.
Design, synthesis, and evaluation of BCL-2 targeting PROTACs.
Chemistry
; : e202400430, 2024 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38818652
2.
4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors.
Bioorg Chem
; 139: 106725, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37442043
3.
Fluorogenic substrates and pre-column derivatization for monitoring the activity of bile salt hydrolase from Clostridium perfringens.
Bioorg Chem
; 138: 106574, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37163789
4.
Cell Type-Specific Anti-Viral Effects of Novel SARS-CoV-2 Main Protease Inhibitors.
Int J Mol Sci
; 24(4)2023 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36835380
5.
Corallopyronin A: antimicrobial discovery to preclinical development.
Nat Prod Rep
; 39(9): 1705-1720, 2022 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35730490
6.
Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain.
Chemistry
; 28(62): e202201636, 2022 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35852812
7.
Combinatorial assembly, traceless generation and in situ evaluation of inhibitors for therapeutically relevant serine proteases.
Bioorg Chem
; 121: 105676, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35202850
8.
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
J Enzyme Inhib Med Chem
; 37(1): 515-526, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35144520
9.
Aminoalkoxy-substituted coumarins: Synthesis and evaluation for reactivation of inhibited human acetylcholinesterase.
Arch Pharm (Weinheim)
; 355(11): e2200208, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-35876340
10.
Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models.
Arch Pharm (Weinheim)
; 355(5): e2100467, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35128717
11.
On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs.
Biochem Biophys Res Commun
; 534: 67-72, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33310190
12.
Discovery of Thanafactin A, a Linear, Proline-Containing Octalipopeptide from Pseudomonas sp. SH-C52, Motivated by Genome Mining.
J Nat Prod
; 84(1): 101-109, 2021 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33382250
13.
Another structural correction for 1-oxo-1H-phenalene-2,3-dicarbonitriles: Synthesis of a potent BCL-2 inhibiting 7-phenoxy derivative.
Arch Pharm (Weinheim)
; 354(10): e2100151, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34173255
14.
2-Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors.
Arch Pharm (Weinheim)
; 354(12): e2100300, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34697820
15.
Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors.
Angew Chem Int Ed Engl
; 60(18): 10423-10429, 2021 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33655614
16.
Lenalidomide and pomalidomide potently interfere with induction of myeloid-derived suppressor cells in multiple myeloma.
Br J Haematol
; 191(5): 784-795, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32558939
17.
Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation as Gαq -Protein Ligands.
Chemistry
; 26(55): 12615-12623, 2020 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32428383
18.
N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization.
Bioorg Med Chem Lett
; 30(18): 127420, 2020 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32763808
19.
ω-Quinazolinonylalkyl aryl ureas as reversible inhibitors of monoacylglycerol lipase.
Bioorg Chem
; 94: 103352, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31668797
20.
Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs.
Molecules
; 25(23)2020 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33276504