1.
Bioorg Med Chem Lett
; 22(3): 1439-44, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22209461
RESUMO
A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity.