Cardiopulmonary Demand of 16-kg Kettlebell Snatches in Simulated Girevoy Sport.

Chan, M, MacInnis, MJ, Koch, S, MacLeod, KE, Lohse, KR, Gallo, ME, Sheel, AW, and Koehle, MS. Cardiopulmonary demand of 16-kg kettlebell snatches in simulated Girevoy Sport. J Strength Cond Res 34(6): 1625-1633, 2020-Kettlebell lifting has become popular both as a strength and conditioning training tool and as a sport in and of itself: Girevoy Sport (GS). Although several kettlebell multimovement protocols have been analyzed, little research has attempted to quantify the aerobic stimulus of the individual events in GS, which could better inform kettlebell-related exercise prescription. The purpose of this study was to quantify the cardiopulmonary demand, assessed primarily by oxygen consumption (V[Combining Dot Above]O2) and heart rate (HR), of continuous high-intensity kettlebell snatches-under conditions relevant to GS-and to compare this demand with a more traditional graded rowing ergometer maximal exercise test. Ten male participants (age = 28.4 ± 4.6 years, height = 185 ± 7 cm, body mass = 95.1 ± 14.9 kg) completed (a) a graded-exercise test on a rowing ergometer to determine maximal oxygen consumption (V[Combining Dot Above]O2max) and maximal heart rate (HRmax) and (b) a graded-exercise test consisting of continuous 16-kg kettlebell snatches to determine peak oxygen consumption (V[Combining Dot Above]O2peak) and peak heart rate (HRpeak) during a simulated GS snatch event. Subjects achieved a V[Combining Dot Above]O2max of 45.7 ± 6.7 ml·kg·min and HRmax of 177 ± 8.3 b·min on the rowing ergometer. The kettlebell snatch test produced a V[Combining Dot Above]O2peak of 37.6 ± 4.4 ml·kg·min (82.7 ± 6.5% V[Combining Dot Above]O2max) and a HRpeak of 174 ± 10 b·min (98.0 ± 3.4% HRmax). These findings suggest that GS kettlebell snatches with 16-kg can provide an adequate aerobic stimulus to improve cardiorespiratory fitness in those with a V[Combining Dot Above]O2max of ≤51 ml·kg·min, according to aerobic training recommendations from the American College of Sports Medicine.

Yerba Mate (Ilex paraguariensis) consumption is associated with higher bone mineral density in postmenopausal women.

Yerba Mate (Ilex paraguariensis) tea consumption is higher in Argentina and other South American countries than those of coffee or tea (Camellia sinensis). The effects of Yerba Mate on bone health have not previously been explored. From a program for osteoporosis prevention and treatment, postmenopausal women who drank at least 1 L of Yerba Mate tea daily during 4 or more years (n=146) were identified, and matched by age and time since menopause with an equal number of women who did not drink Yerba Mate tea. Their bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) at the lumbar spine and femoral neck. Yerba Mate drinkers had a 9.7% higher lumbar spine BMD (0.952 g/cm(2) versus 0.858 g/cm(2): p<0.0001) and a 6.2% higher femoral neck BMD (0.817 g/cm(2) versus 0.776 g/cm(2); p=0.0002). In multiple regression analysis, Yerba Mate drinking was the only factor, other than body mass index, which showed a positive correlation with BMD at both the lumbar spine (p<0.0001) and the femoral neck (p=0.0028). Results suggest a protective effect of chronic Yerba Mate consumption on bone.

Alpha-catalytic subunits of 5'AMP-activated protein kinase display fiber-specific expression and are upregulated by chronic low-frequency stimulation in rat muscle.

5'-AMP-activated protein kinase (AMPK) signaling initiates adaptive changes in skeletal muscle fibers that restore homeostatic energy balance. The purpose of this investigation was to examine, in rats, the fiber-type protein expression patterns of the alpha-catalytic subunit isoforms in various skeletal muscles, and changes in their respective contents within the tibialis anterior (TA) after chronic low-frequency electrical stimulation (CLFS; 10 Hz, 10 h daily), applied for 4 +/- 1.2 or 25 +/- 4.8 days. Immunocytochemical staining of soleus (SOL) and medial gastrocnemius (MG) showed that 86 +/- 4.1 to 97 +/- 1.4% of type IIA fibers stained for both the alpha1- and alpha2-isoforms progressively decreased to 63 +/- 12.2% of type IID/X and 9 +/- 2.4% of IIB fibers. 39 +/- 11.4% of IID/X and 83 +/- 7.9% of IIB fibers expressed only the alpha2 isoform in the MG, much of which was localized within nuclei. alpha1 and alpha2 contents, assessed by immunoblot, were lowest in the white gastrocnemius [WG; 80% myosin heavy chain (MHC) IIb; 20% MHCIId/x]. Compared with the WG, alpha1 content was 1.6 +/- 0.08 (P < 0.001) and 1.8 +/- 0.04 (P < 0.0001)-fold greater in the red gastrocnemius (RG: 13%, MHCIIa) and SOL (21%, MHCIIa), respectively, and increased in proportion to MHCIIa content. Similarly, alpha2 content was 1.4 +/- 0.10 (P < 0.02) and 1.5 +/- 0.07 (P < 0.001)-fold greater in RG and SOL compared with WG. CLFS induced 1.43 +/- 0.13 (P < 0.007) and 1.33 +/- 0.08 (P < 0.009)-fold increases in the alpha1 and alpha2 contents of the TA and coincided with the transition of faster type IIB and IID/X fibers toward IIA fibers. These findings indicate that fiber types differ with regard to their capacity for AMPK signaling and that this potential is increased by CLFS.

Reactional states in multibacillary Hansen disease patients during multidrug therapy

Reacoes sao ocorrencias comuns no curso da hanseniase e sao responsaveis pelo agravamento das lesoes neurais. Uma coorte de 162 pacientes recem-diagnosticados, baciloscopicamente positivos, em acompanhamento no Ambulatorio de Hanseniase da Fundacao Oswaldo Cruz (FIOCRUZ) foi selecionada para estudo. Observou-se que 46 por cento dos pacientes multibacilares submetidos a 24 doses fixas de poliquimioterapia (PQT) apresentaram reacoes durante o tratamento; todos multibacilares eram suscetiveis e cuidados e atencao constantes eram necessarios. Quatorze por cento foram classificados como BB, 52 por cento como BL e 33 por cento foram classificados como LL. Nenhuma das variaveis em estudo, tais como: sexo, idade, forma clinica, tempo de doenca, extensao das lesoes dermatologicas, indice baciloscopico (IB), ou grau de incapacidade associaram-se a reacao entre os pacientes estudados...

Características clínico-histopatológicas dos estados reacionais na hanseníase em pacientes submetidos à poliquimioterapia (PQT) / Clinical and histopathological characteristics of reactional states in leprosy patients submitted to multi-drug therapy

O objetivo deste estudo foi analisar os aspectos clínicos e histopatológicos dos estados reacionais em 169 pacientes multibacilares submetidos à poliquimioterapia. Em adiçäo foram avaliadas a frequência e a distribuiçäo desses episódios reacionais. Os casos foram classificados, com base nos dados clínicos e histopatológicos, em eritema nodoso hansênico - ENH (51 porcento), reaçäo reversa - RR (42 porcento) e neurite isolada (7 porcento). Verificou-se que os episódios reacionais säo complicaçäo freqüente (59 porcento) e ocorrem em qualquer momento no curso da doença. Observou-se que 77 porcento dos pacientes que desenvolveram ENH e 43 porcento dos pacientes com RR apresentaram manifestaçöes sistêmicas. A RR predominou entre os pacientes portadores da forma borderline-borderline (74 porcento), enquanto o ENH predominou naqueles diagnosticados pela forma lepromatosa-lepromatosa (86 porcento). O ENH foi significativamente mais recorrente do que a RR, que predominou no primeiro ano de PQT, enquanto o ENH no segundo ano

Reactional states in multibacilary hansen disease patients during multidrug therapy

It is well known that reactions are commonplace occurrences during the course of leprosy disease. Stigmatization may even be attributable to reactions which are also responsible for the worsening of neural lesions. A cohort of 162 newly-diagnosed baciloscopically positive patients from the Leprosy Care Outpatient Clinic of the Oswaldo Cruz Foundation (FIOCRUZ) was selected for this study. While 46% of the multibacillary (MB) patients submitted to the 24 fixed-dose multidrug therapy (MDT) regimen suffered reactions during treatment, it was found that all MBs were susceptible and that constant attention and care were required at all times. Fourteen per cent were classified as BB, 52% as BL, and 33% as LL. None of the variables under study, such as, sex, age, clinical form, length of illness, length of dermatological lesions, baciloscopic index (BI), or degree of disability proved to be associate with reaction among the patients studied. Reversal Reaction (RR) occurred in 45%, and Erythema Nodosum Leprosum (ENL) occurred in 55%. Among BB patients who developed reactions (15 patients), 93% presented RR; while among the LL patients who developed reactions (34 patients), 91% presented ENL. Likewise, ENL was very frequent among those with disseminate lesions, while RR was most often observed in patients with segmentary lesions. RR was also most likely to occur during the initial months of treatment. It was demonstrated that the recurrence rate of ENL was significantly higher than that of RR. Neither grade of disability nor BI was shown to be associated with RR and ENL reaction. However, the RR rate was significantly higher among patients showing BI 3