RESUMO
Iodine in 2% oleum is an efficient catalyst for the selective, high yield oxidation of methane to methyl bisulfate.
Assuntos
Comitês de Cuidado Animal/organização & administração , Animais de Laboratório , Pesquisa Biomédica/normas , Educação em Veterinária/normas , Educação/normas , Projetos de Pesquisa/normas , Comitês de Cuidado Animal/legislação & jurisprudência , Animais , Pesquisa Biomédica/legislação & jurisprudência , Educação/legislação & jurisprudência , Educação em Veterinária/legislação & jurisprudência , Projetos de Pesquisa/legislação & jurisprudênciaRESUMO
Cynomolgus macaques exposed to an aerosol containing a virulent strain of eastern equine encephalitis (EEE) virus developed neurological signs indicating encephalitis that corresponded with the onset of fever and an elevated heart rate. Viremia was either transient or undetectable even in animals that succumbed to the illness. The onset of illness was dose dependent, but once a febrile response was observed, macaques were moribund within 36 h. Simultaneously, a prominent leukocytosis was seen; 1 day before being moribund, macaques had a white blood cell count >20,000 cells/ microL. The leukocytes were predominantly granulocytes. Increases in serum levels of blood urea nitrogen, sodium, and alkaline phosphatase were also seen. The rapid onset and severity of neurological signs mirror what has been reported for human cases of disease caused by EEE.