Bonding states of gold/silver plasmonic nanostructures and sulfur-containing active biological ingredients in biomedical applications: a review.

As one of the most instrumental components in the architecture of advanced nanomedicines, plasmonic nanostructures (mainly gold and silver nanomaterials) have been paid a lot of attention. This type of nanomaterial can absorb light photons with a specific wavelength and generate heat or excited electrons through surface resonance, which is a unique physical property. In innovative biomaterials, a significant number of theranostic (therapeutic and diagnostic) materials are produced through the conjugation of thiol-containing ingredients with gold and silver nanoparticles (Au and Ag NPs). Hence, it is essential to investigate Au/Ag-S interfaces precisely and determine the exact bonding states in the active nanobiomaterials. This study intends to provide useful insights into the interactions between Au/Ag NPs and thiol groups that exist in the structure of biomaterials. In this regard, the modeling of Au/Ag-S bonding in active biological ingredients is precisely reviewed. Then, the physiological stability of Au/Ag-based plasmonic nanobioconjugates in real physiological environments (pharmacokinetics) is discussed. Recent experimental validation and achievements of plasmonic theranostics and radiolabelled nanomaterials based on Au/Ag-S conjugation are also profoundly reviewed. This study will also help researchers working on biosensors in which plasmonic devices deal with the thiol-containing biomaterials (e.g., antibodies) inside blood serum and living cells.

Applications of hollow nanostructures in water treatment considering organic, inorganic, and bacterial pollutants.

One of the major issues of modern society is water contamination with different organic, inorganic, and contaminants bacteria. Finding cost-effective and efficient materials and methods for water treatment and environment remediation is among the scientists' most important considerations. Hollow-structured nanomaterials, including hollow fiber membranes, hollow spheres, hollow nanoboxes, etc., have shown an exciting capability for wastewater refinement approaches, including membrane technology, adsorption, and photocatalytic procedure due to their extremely high specific surface area, high porosity, unique morphology, and low density. Diverse hollow nanostructures could potentially eliminate organic contaminants, including dyes, antibiotics, oil/water emulsions, pesticides, and other phenolic compounds, inorganic pollutants, such as heavy metal ions, salts, phosphate, bromate, and other ions, and bacteria contaminations. Here, a comprehensive overview of hollow nanostructures' fabrication and modification, water contaminant classification, and recent studies in the water treatment field using hollow-structured nanomaterials with a comparative attitude have been provided, indicating the privilege abd detriments of this class of nanomaterials. Eventually, the future outlook of employing hollow nanomaterials in water refinery systems and the upcoming challenges arising in scaling up are also propounded.

Fabrication and characterization of a novel magnetic nanostructure based on pectin-cellulose hydrogel for in vitro hyperthermia during cancer therapy.

Herein, a new magnetic nanobiocomposite based on a synthesized cross-linked pectin-cellulose hydrogel (cross-linked Pec-Cel hydrogel) substrate was designed and synthesized. The formation of the cross-linked Pec-Cel hydrogel with a calcium chloride agent and its magnetization process caused a new and efficient magnetic nanobiocomposite. Several spectral and analytical techniques, including FTIR, SEM, VSM, TGA, XRD, and EDX analyses, were performed to confirm and characterize the structural features of the magnetic cross-linked pectin-cellulose hydrogel nanobiocomposite (magnetic cross-linked Pec-Cel hydrogel nanobiocomposite). Based on SEM images, prepared Fe3O4 magnetic nanoparticles (MNPs) were uniformly dispersed in the Pec-Cel hydrogel context, representing an average particle size between 50.0 and 60.0 nm. The XRD pattern also confirms the crystallinity of the magnetic nanobiocomposite. All constituent elements and their distribution have been depicted in the EDX analysis of the magnetic nanobiocomposite. VSM curves confirmed the superparamagnetic behavior of Fe3O4 MNPs and the magnetic nanobiocomposite with a saturation magnetization of 77.31 emu g-1 and 48.80 emu g-1, respectively. The thermal stability of the nanobiocomposite was authenticated to ca. 800 °C based on the TGA thermogram. Apart from analyzing the structural properties of the magnetic cross-linked Pec-Cel hydrogel nanobiocomposite, different concentrations (0.5 mg mL-1, 1.0 mg mL-1, 2.0 mg mL-1, 5.0 mg mL-1, and 10.0 mg mL-1) of this new magnetic nanostructure were exposed to an alternating magnetic field (AMF) at different frequencies (100.0 MHz, 200.0 MHz, 300.0 MHz, and 400.0 MHz) to evaluate its capacity for an in vitro hyperthermia process; in addition, the highest specific absorption rate (126.0 W g-1) was obtained by the least magnetic nanobiocomposite concentration (0.5 mg mL-1).

Effects of mechanical properties of carbon-based nanocomposites on scaffolds for tissue engineering applications: a comprehensive review.

Mechanical properties, such as elasticity modulus, tensile strength, elongation, hardness, density, creep, toughness, brittleness, durability, stiffness, creep rupture, corrosion and wear, a low coefficient of thermal expansion, and fatigue limit, are some of the most important features of a biomaterial in tissue engineering applications. Furthermore, the scaffolds used in tissue engineering must exhibit mechanical and biological behaviour close to the target tissue. Thus, a variety of materials has been studied for enhancing the mechanical performance of composites. Carbon-based nanostructures, such as graphene oxide (GO), reduced graphene oxide (rGO), carbon nanotubes (CNTs), fibrous carbon nanostructures, and nanodiamonds (NDs), have shown great potential for this purpose. This is owing to their biocompatibility, high chemical and physical stability, ease of functionalization, and numerous surface functional groups with the capability to form covalent bonds and electrostatic interactions with other components in the composite, thus significantly enhancing their mechanical properties. Considering the outstanding capabilities of carbon nanostructures in enhancing the mechanical properties of biocomposites and increasing their applicability in tissue engineering and the lack of comprehensive studies on their biosafety and role in increasing the mechanical behaviour of scaffolds, a comprehensive review on carbon nanostructures is provided in this study.

A Mesoporous Magnetic Fe3O4/BioMOF-13 with a Core/Shell Nanostructure for Targeted Delivery of Doxorubicin to Breast Cancer Cells.

In the current project, magnetic Bio-MOF-13 was used as an efficient carrier for the targeted delivery and controlled release of doxorubicin (DOX) to MDA-MB-231 cells. Magnetic Bio-MOF-13 was prepared by two strategies and compared to determine the optimal state of the structure. In the first path, Bio-MOF-13 was grown in situ on the surface of Fe3O4 nanoparticles (core/shell structure), while in the second method, the two presynthesized materials were mixed together (surface composite). Core/shell structure, among prepared nanocomposites, was chosen for biological evaluation due to its favorable structural features like a high accessible surface area and pore volume. Also, it is highly advantageous for drug release due to its ability to selectively release DOX in the acidic pH of breast cancer cells, while preventing any premature release in the neutral pH of the blood. Drug release from the carrier structure is precisely controlled not only by pH but also by an external magnetic field, guaranteeing accurate drug delivery at the intended location. Confocal microscopy and flow cytometry assay clearly confirms the increase in drug concentration in the MDA-MB-231 cell line after external magnet applying. This point, along with the low toxicity of the carrier components, makes it a suitable candidate for injectable medicine. According to MTT results, the percentage of viable MDA-MB-231 cells after treatment with 10 µL of DOX@Fe3O4/Bio-MOF-13 core/shell composite in different concentrations, in the presence and absence of magnetic field is 0.87 ± 0.25 and 2.07 ± 0.15, respectively. As a result, the DOX@Fe3O4/Bio-MOF-13 core/shell composite was performed and approved for targeted drug delivery and magnetic field-assisted controlled release of DOX to the MDA-MB-231 cell line.