Detalhe da pesquisa
1.
Administration mode matters for 5-fluorouracil therapy: Physiologically based pharmacokinetic evidence for avoidance of myelotoxicity by continuous infusion but not intravenous bolus.
Br J Clin Pharmacol
; 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38627941
2.
Exploring the impact of ethnicity on drug pharmacokinetics using PBPK models: A case study with lansoprazole in Japanese subjects.
Br J Clin Pharmacol
; 2023 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38072775
3.
Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Drug Metab Dispos
; 50(7): 957-967, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35504655
4.
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities.
Xenobiotica
; 52(8): 840-854, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36214113
5.
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models.
Xenobiotica
; 52(8): 943-956, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36222269
6.
Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons.
Arch Toxicol
; 95(6): 2081-2107, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33778899
7.
Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling.
Arch Toxicol
; 95(12): 3695-3716, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34628512
8.
A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates.
Drug Metab Dispos
; 48(11): 1231-1238, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32893186
9.
Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed Physiologically-Based Pharmacokinetic Model of Ritonavir Norvir Tablet Absorption in Humans Under Fasted and Fed State Conditions.
Mol Pharm
; 17(7): 2329-2344, 2020 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32427480
10.
Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits.
Mol Pharm
; 17(2): 588-594, 2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31794668
11.
Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals.
Arch Toxicol
; 94(8): 2707-2729, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32607615
12.
Correction to: Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals.
Arch Toxicol
; 94(8): 2731-2732, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32720191
13.
Comparative Cerebroprotective Potential of d- and l-Carnosine Following Ischemic Stroke in Mice.
Int J Mol Sci
; 21(9)2020 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32357505
14.
Mathematical modelling of a liver hollow fibre bioreactor.
J Theor Biol
; 475: 25-33, 2019 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31100294
15.
Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants.
Arch Toxicol
; 93(6): 1585-1608, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31190196
16.
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
Arch Toxicol
; 93(6): 1609-1637, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31250071
17.
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.
Arch Toxicol
; 92(12): 3505-3515, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30317417
18.
Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.
Arch Toxicol
; 92(12): 3517-3533, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30511339
19.
Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum.
Regul Toxicol Pharmacol
; 99: 5-21, 2018 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30144470
20.
Adverse outcome pathways: opportunities, limitations and open questions.
Arch Toxicol
; 91(11): 3477-3505, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29051992