Detalhe da pesquisa
1.
Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases.
J Pept Sci
; 24(1)2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29322647
2.
Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.
J Org Chem
; 82(7): 3506-3512, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28319665
3.
Synthesis of relaxin-2 and insulin-like peptide 5 enabled by novel tethering and traceless chemical excision.
J Pept Sci
; 23(6): 455-465, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28466571
4.
Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity.
J Pept Sci
; 21(3): 223-30, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25665061
5.
Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems.
Mol Metab
; 66: 101638, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36400403
6.
Functional association of the N-terminal residues with the central region in glucagon-related peptides.
J Pept Sci
; 17(10): 659-66, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21661079
7.
Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action.
J Pept Sci
; 17(3): 218-25, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21308878
8.
Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists.
J Med Chem
; 64(8): 4697-4708, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33821647
9.
Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence.
J Med Chem
; 63(11): 6134-6143, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32406685
10.
Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice.
Peptides
; 120: 170116, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31348991
11.
A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity.
ACS Chem Biol
; 14(8): 1829-1835, 2019 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31343157
12.
High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy.
Org Lett
; 20(12): 3695-3699, 2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29874090
13.
Synthesis and Characterization of the R27S Genetic Variant of Insulin-like Peptide 5.
ChemMedChem
; 13(8): 852-859, 2018 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29466617
14.
Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity.
Peptides
; 100: 18-23, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29412818
15.
Chemical synthesis of insulin analogs through a novel precursor.
ACS Chem Biol
; 9(3): 683-91, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24328449
16.
A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction.
Mol Metab
; 2(2): 86-91, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24199154
17.
Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker.
ACS Chem Biol
; 8(8): 1822-9, 2013 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23730814
18.
Peptide lipidation stabilizes structure to enhance biological function.
Mol Metab
; 2(4): 468-79, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24327962
19.
A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.
ACS Chem Biol
; 6(2): 135-45, 2011 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20939591
20.
Optimization of the native glucagon sequence for medicinal purposes.
J Diabetes Sci Technol
; 4(6): 1322-31, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21129326