Detalhe da pesquisa
1.
A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer.
Breast Cancer Res
; 20(1): 109, 2018 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30185228
2.
Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial.
Lancet Oncol
; 17(6): 811-821, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-27155741
3.
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.
Bioorg Med Chem Lett
; 22(24): 7653-8, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23127890
4.
EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation.
Clin Cancer Res
; 14(8): 2465-75, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18413839
5.
Low-pass Whole-genome Sequencing of Circulating Cell-free DNA Demonstrates Dynamic Changes in Genomic Copy Number in a Squamous Lung Cancer Clinical Cohort.
Clin Cancer Res
; 25(7): 2254-2263, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617129
6.
Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN Loss.
Clin Cancer Res
; 25(3): 928-936, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30037818
7.
Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647.
Clin Cancer Res
; 13(12): 3713-23, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17575237
8.
Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry - Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort.
J Thorac Oncol
; 13(12): 1851-1863, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30240851
9.
Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA.
J Mol Diagn
; 20(5): 686-702, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29936259
10.
Chromosomal Instability Estimation Based on Next Generation Sequencing and Single Cell Genome Wide Copy Number Variation Analysis.
PLoS One
; 11(11): e0165089, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27851748
11.
Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant.
Nat Commun
; 7: 11579, 2016 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27174596
12.
Phase II Randomized Preoperative Window-of-Opportunity Study of the PI3K Inhibitor Pictilisib Plus Anastrozole Compared With Anastrozole Alone in Patients With Estrogen Receptor-Positive Breast Cancer.
J Clin Oncol
; 34(17): 1987-94, 2016 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26976426
13.
Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans.
Dev Biol
; 260(1): 273-86, 2003 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12885569